CTNNB1 anticorps (C-Term)

N° du produit ABIN1881238

Cet anticorps Lapin Polyclonal détecte spécifiquement CTNNB1 dans WB, IF, FACS et IHC (p). Il présente une réactivité avec des échantillons de Humain. Il a été cité dans 5+ publications.

Aperçu rapide pour CTNNB1 anticorps (C-Term) (ABIN1881238)

Antigène: CTNNB1 (Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CTNNB1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB41124

Détail du produit anti-CTNNB1 anticorps

Épitope: AA 692-721, C-Term

Homologie: B, Zf, M, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This CTNNB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 692-721 amino acids from the C-terminal region of human CTNNB1.

Isotype: Ig Fraction

Information d'application

Indications d'application: IF: 1:50. IF: 1:50. WB: 1:2000. IHC-P: 1:50. IHC-P: 1:50. FC: 1:50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-CTNNB1 (ABIN1881238)

Huang, Wang, Guo, Jia, Lin, Li, Wang, Chen: "Approaching the intrinsic electron field-emission of a graphene film consisting of quasi-freestanding graphene strips." dans: Small (Weinheim an der Bergstrasse, Germany), Vol. 7, Issue 4, pp. 450-4, (2011) (PubMed).

Huang, Zhou, Saberwal, Konieczna, Horvath, Katsoulidis, Platanias, Eklund: "Interferon consensus sequence binding protein (ICSBP) decreases beta-catenin activity in myeloid cells by repressing GAS2 transcription." dans: Molecular and cellular biology, Vol. 30, Issue 19, pp. 4575-94, (2010) (PubMed).

Chairoungdua, Smith, Pochard, Hull, Caplan: "Exosome release of ?-catenin: a novel mechanism that antagonizes Wnt signaling." dans: The Journal of cell biology, Vol. 190, Issue 6, pp. 1079-91, (2010) (PubMed).

Mirza, Sun, Zhao, Potula, Frey, Vogel, Malik, Zhao: "FoxM1 regulates re-annealing of endothelial adherens junctions through transcriptional control of beta-catenin expression." dans: The Journal of experimental medicine, Vol. 207, Issue 8, pp. 1675-85, (2010) (PubMed).

Teng, Wang, Wang, Wang: "[Effect of siRNA-mediated beta-catenin gene on Wnt signal pathway in lung adenocarcinoma A549 cell]." dans: Zhonghua yi xue za zhi, Vol. 90, Issue 14, pp. 988-92, (2010) (PubMed).

Détails sur CTNNB1

Antigène: CTNNB1 (Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1))

Autre désignation: CTNNB1

Sujet: The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.

Poids moléculaire: 85497

NCBI Accession: NP_001091679, NP_001091680, NP_001895

UniProt: P35222

Pathways: Signalisation WNT, Intracellular Steroid Hormone Receptor Signaling Pathway, Peptide Hormone Metabolism, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Tube Formation, Maintenance of Protein Location, Signaling Events mediated by VEGFR1 and VEGFR2