CXCR4 anticorps (N-Term)

N° du produit ABIN1881244

Cet anticorps Lapin Polyclonal détecte spécifiquement CXCR4 dans WB. Il présente une réactivité envers Humain et a été mentionné dans 6+ publications.

Aperçu rapide pour CXCR4 anticorps (N-Term) (ABIN1881244)

Antigène: CXCR4 (Chemokine (C-X-C Motif) Receptor 4 (CXCR4))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CXCR4 est non-conjugé

Application: Western Blotting (WB)

Clone: RB41207

Détail du produit anti-CXCR4 anticorps

Épitope: AA 50-79, N-Term

Homologie: B, Pr, M, Pig, Rat, Sh

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This CXCR4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 50-79 amino acids from the N-terminal region of human CXCR4.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-CXCR4 (ABIN1881244)

Zhou, Liu, Li, Zhang, Wang, Lan, Shi, Li, Ju: "Migration ability and Toll-like receptor expression of human mesenchymal stem cells improves significantly after three-dimensional culture." dans: Biochemical and biophysical research communications, Vol. 491, Issue 2, pp. 323-328, (2017) (PubMed).

Zhu, Hong, Tripathi, Sehdev, Belkhiri, El-Rifai: "Regulation of CXCR4-mediated invasion by DARPP-32 in gastric cancer cells." dans: Molecular cancer research : MCR, Vol. 11, Issue 1, pp. 86-94, (2013) (PubMed).

Hammad, Kuang, Yan, Allen, Dupré: "Na+/H+ exchanger regulatory factor-1 is involved in chemokine receptor homodimer CCR5 internalization and signal transduction but does not affect CXCR4 homodimer or CXCR4-CCR5 heterodimer." dans: The Journal of biological chemistry, Vol. 285, Issue 45, pp. 34653-64, (2010) (PubMed).

Wang, Guilpain, Chong, Chouzenoux, Guillevin, Du, Zhou, Lin, Fairhurst, Boudreaux, Roux, Wakeland, Davis, Batteux, Mohan: "Dysregulated expression of CXCR4/CXCL12 in subsets of patients with systemic lupus erythematosus." dans: Arthritis and rheumatism, Vol. 62, Issue 11, pp. 3436-46, (2010) (PubMed).

Cheng, Zhou, Wu, Boriboun, Thorne, Liu, Xiang, Zeng, Tanaka, Tang, Kishore, Tomasson, Miller, Losordo, Qin: "CXCR4-mediated bone marrow progenitor cell maintenance and mobilization are modulated by c-kit activity." dans: Circulation research, Vol. 107, Issue 9, pp. 1083-93, (2010) (PubMed).

Sanematsu, Hirashima, Laurin, Takii, Nishikimi, Kitajima, Ding, Noda, Murata, Tanaka, Masuko, Suda, Meno, C��té, Nagasawa, Fukui: "DOCK180 is a Rac activator that regulates cardiovascular development by acting downstream of CXCR4." dans: Circulation research, Vol. 107, Issue 9, pp. 1102-5, (2010) (PubMed).

Détails sur CXCR4

Antigène: CXCR4 (Chemokine (C-X-C Motif) Receptor 4 (CXCR4))

Autre désignation: CXCR4

Sujet: This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq].

Poids moléculaire: 39746

NCBI Accession: NP_001008540, NP_003458

UniProt: P61073

Pathways: Regulation of Cell Size, CXCR4-mediated Signaling Events