CDKN1B anticorps (pThr197)

N° du produit ABIN1881619

Cet anticorps Lapin Polyclonal détecte spécifiquement CDKN1B dans DB. Il présente une réactivité envers Souris et a été mentionné dans 5+ publications.

Aperçu rapide pour CDKN1B anticorps (pThr197) (ABIN1881619)

Antigène: CDKN1B (Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CDKN1B est non-conjugé

Application: Dot Blot (DB)

Clone: RB42131

Détail du produit anti-CDKN1B anticorps

Épitope: pThr197

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This mouse p27Kip1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T197 of mouse p27Kip1.

Isotype: Ig Fraction

Information d'application

Indications d'application: DB: 1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-CDKN1B (ABIN1881619)

Singh, Jatzek, Plisch, Srinivasan, Svaren, Suresh: "Regulation of memory CD8 T-cell differentiation by cyclin-dependent kinase inhibitor p27Kip1." dans: Molecular and cellular biology, Vol. 30, Issue 21, pp. 5145-59, (2010) (PubMed).

Antico-Arciuch, Dima, Liao, Refetoff, Di Cristofano: "Cross-talk between PI3K and estrogen in the mouse thyroid predisposes to the development of follicular carcinomas with a higher incidence in females." dans: Oncogene, Vol. 29, Issue 42, pp. 5678-86, (2010) (PubMed).

Mitsuhashi, Yonemoto, Sone, Kosuge, Kosaki, Takahashi: "In utero exposure to dioxin causes neocortical dysgenesis through the actions of p27Kip1." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 37, pp. 16331-5, (2010) (PubMed).

Zhang, Li, Yuan, Tian, Weidenfeld, Yang, Liu, Chokas, Morrisey: "Foxp1 coordinates cardiomyocyte proliferation through both cell-autonomous and nonautonomous mechanisms." dans: Genes & development, Vol. 24, Issue 16, pp. 1746-57, (2010) (PubMed).

Wang, Li, Jiao, Zhang, Shao, Yuan, Yu: "RNA interference reveals a requirement for both p18INK4c and p27Kip1 in B lymphopoiesis." dans: Journal of molecular cell biology, Vol. 2, Issue 4, pp. 209-16, (2010) (PubMed).

Détails sur CDKN1B

Antigène: CDKN1B (Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B))

Autre désignation: p27Kip1

Sujet: This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. [provided by RefSeq].

Poids moléculaire: 22193

NCBI Accession: NP_034005

UniProt: P46414

Pathways: Cycle Cellulaire, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Negative Regulation of Hormone Secretion, Sensory Perception of Sound, Mitotic G1-G1/S Phases, DNA Replication, Positive Regulation of Endopeptidase Activity, Synthesis of DNA, Autophagy