CDKN1B anticorps (pSer140)

N° du produit ABIN1881621

Cet anticorps anti-CDKN1B est un anticorps Lapin Polyclonal détectant CDKN1B dans DB. Adapté pour Humain. Ce Primary Antibody a été cité dans 4+ publications.

Aperçu rapide pour CDKN1B anticorps (pSer140) (ABIN1881621)

Antigène: CDKN1B (Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CDKN1B est non-conjugé

Application: Dot Blot (DB)

Clone: RB42099

Détail du produit anti-CDKN1B anticorps

Épitope: pSer140

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This p27Kip1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S140 of human p27Kip1.

Isotype: Ig Fraction

Information d'application

Indications d'application: DB: 1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-CDKN1B (ABIN1881621)

Kajihara, Fukushige, Shioda, Tanabe, Fukunaga, Inui: "CaMKII phosphorylates serine 10 of p27 and confers apoptosis resistance to HeLa cells." dans: Biochemical and biophysical research communications, Vol. 401, Issue 3, pp. 350-5, (2010) (PubMed).

Kedde, van Kouwenhove, Zwart, Oude Vrielink, Elkon, Agami: "A Pumilio-induced RNA structure switch in p27-3' UTR controls miR-221 and miR-222 accessibility." dans: Nature cell biology, Vol. 12, Issue 10, pp. 1014-20, (2010) (PubMed).

Canbay, Eraltan, Cercel, Isbir, Gazioglu, Aydogan, Cacina, Cengiz, Ferahman, Zengin, Unal: "CCND1 and CDKN1B polymorphisms and risk of breast cancer." dans: Anticancer research, Vol. 30, Issue 7, pp. 3093-8, (2010) (PubMed).

Do Nascimento Borges, Burbano, Harada: "Absence of CIP1/KIP1 hypermethylation in gastric cancer patients from Northern Brazil." dans: In vivo (Athens, Greece), Vol. 24, Issue 4, pp. 579-82, (2010) (PubMed).

Détails sur CDKN1B

Antigène: CDKN1B (Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B))

Autre désignation: p27Kip1

Sujet: This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. [provided by RefSeq].

Poids moléculaire: 22073

NCBI Accession: NP_004055

UniProt: P46527

Pathways: Cycle Cellulaire, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Negative Regulation of Hormone Secretion, Sensory Perception of Sound, Mitotic G1-G1/S Phases, DNA Replication, Positive Regulation of Endopeptidase Activity, Synthesis of DNA, Autophagy