TSC1 anticorps (pSer1141)

N° du produit ABIN1881906

Détail du produit anti-TSC1 anticorps

Antigène: TSC1 (Tuberous Sclerosis 1 (TSC1))

Épitope: pSer1141

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TSC1 est non-conjugé

Application: Dot Blot (DB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This rat TSC1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S1141 of rat TSC1.

Clone: RB41265

Isotype: Ig Fraction

Information d'application

Indications d'application: DB: 1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-TSC1 (ABIN1881906)

Inoue, Ndong, Suzuki, Kazami, Uyama, Kobayashi, Tadokoro, Yamamoto: "Hamartin-Hsp70 interaction is necessary for Akt-dependent tuberin phosphorylation during heat shock." dans: Bioscience, biotechnology, and biochemistry, Vol. 73, Issue 11, pp. 2488-93, (2009) (PubMed).

Di Nardo, Kramvis, Cho, Sadowski, Meikle, Kwiatkowski, Sahin: "Tuberous sclerosis complex activity is required to control neuronal stress responses in an mTOR-dependent manner." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 29, Issue 18, pp. 5926-37, (2009) (PubMed).

Chen, Yan, Chen, He: "The variation of AkT/TSC1-TSC1/mTOR signal pathway in hepatocytes after partial hepatectomy in rats." dans: Experimental and molecular pathology, Vol. 86, Issue 2, pp. 101-7, (2009) (PubMed).

Momose, Kobayashi, Tada, Itoyama, Hino: "N-terminal hamartin-binding and C-terminal GAP domain of tuberin can separate in vivo." dans: Biochemical and biophysical research communications, Vol. 356, Issue 3, pp. 693-8, (2007) (PubMed).

Détails sur TSC1

Antigène: TSC1 (Tuberous Sclerosis 1 (TSC1))

Autre désignation: TSC1 (TSC1 Produits)

Synonymes: anticorps LAM, anticorps TSC, anticorps hamartin, anticorps mKIAA0243, anticorps tsc1, anticorps wu:fc38b04, anticorps fa99f04, anticorps wu:fa99f04, anticorps zgc:63657, anticorps TSC complex subunit 1, anticorps tuberous sclerosis 1, anticorps TSC complex subunit 1b, anticorps TSC complex subunit 1a, anticorps TSC1, anticorps Tsc1, anticorps tsc1b, anticorps tsc1, anticorps tsc1a

Sujet: In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (By similarity). Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (By similarity).

Poids moléculaire: 129022

NCBI Accession: NP_068626

UniProt: Q9Z136

Pathways: Signalisation RTK, AMPK Signaling, Regulation of Cell Size, Tube Formation