Tuberin anticorps (AA 1364-1393)

N° du produit ABIN1881944

L’anticorps anti-Tuberin Polyclonal Lapin est utilisé pour la détection de Tuberin dans des échantillons de Humain. Il a été validé pour WB.

Aperçu rapide pour Tuberin anticorps (AA 1364-1393) (ABIN1881944)

Antigène: Tuberin (TSC2) (Tuberous Sclerosis 2 (TSC2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Tuberin est non-conjugé

Application: Western Blotting (WB)

Clone: RB42286

Détail du produit anti-Tuberin anticorps

Épitope: AA 1364-1393

Homologie: M, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This TSC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1364-1393 amino acids from the Central region of human TSC2.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur Tuberin

Antigène: Tuberin (TSC2) (Tuberous Sclerosis 2 (TSC2))

Autre désignation: TSC2

Sujet: In complex with TSC1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. Stimulates weakly the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 in vitro. Mutations in TSC2 lead to constitutive activation of RAP1A in tumors.

Poids moléculaire: 200608

NCBI Accession: NP_000539, NP_001070651, NP_001107854

UniProt: P49815

Pathways: Signalisation RTK, AMPK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Cell Size, Tube Formation, Protein targeting to Nucleus