Ret Proto-Oncogene anticorps

N° du produit ABIN1882126

Cet anticorps Lapin Polyclonal détecte spécifiquement Ret Proto-Oncogene dans WB. Il présente une réactivité avec des échantillons de Humain. Il a été cité dans 4+ publications.

Aperçu rapide pour Ret Proto-Oncogene anticorps (ABIN1882126)

Antigène: Ret Proto-Oncogene (RET)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Ret Proto-Oncogene est non-conjugé

Application: Western Blotting (WB)

Clone: RB17715

Détail du produit anti-Ret Proto-Oncogene anticorps

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This RET antibody is generated from rabbits immunized with His fusion protein of human RET.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-Ret Proto-Oncogene (ABIN1882126)

Siqueira, Romitti, da Rocha, Ceolin, Meotti, Estivalet, Puñales, Maia: "The RET polymorphic allele S836S is associated with early metastatic disease in patients with hereditary or sporadic medullary thyroid carcinoma." dans: Endocrine-related cancer, Vol. 17, Issue 4, pp. 953-63, (2010) (PubMed).

Gockel, Schumacher, Gockel, Lang, Haaf, Nöthen: "Achalasia: will genetic studies provide insights?" dans: Human genetics, Vol. 128, Issue 4, pp. 353-64, (2010) (PubMed).

Kim, Jung, Lim, Sung, Whang, Jo, Lee, Shin, Kim, Ryu, Kim: "A study of RET proto-oncogene polymorphisms in association with lung cancer risk in the Korean population." dans: Anticancer research, Vol. 30, Issue 9, pp. 3621-7, (2010) (PubMed).

Pacini, Castagna, Cipri, Schlumberger: "Medullary thyroid carcinoma." dans: Clinical oncology (Royal College of Radiologists (Great Britain)), Vol. 22, Issue 6, pp. 475-85, (2010) (PubMed).

Détails sur Ret Proto-Oncogene

Antigène: Ret Proto-Oncogene (RET)

Autre désignation: RET

Sujet: This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed.

Poids moléculaire: 124319

NCBI Accession: NP_065681, NP_066124

UniProt: P07949

Pathways: Signalisation RTK, Dopaminergic Neurogenesis, Regulation of Cell Size, Tube Formation