YWHAB anticorps (N-Term)

N° du produit ABIN1882154

L’anticorps Lapin Polyclonal anti-YWHAB a été validé pour WB et IHC (p). Il convient pour détecter YWHAB dans des échantillons de Humain. Il y a 8+ publications disponibles.

Aperçu rapide pour YWHAB anticorps (N-Term) (ABIN1882154)

Antigène: YWHAB (14-3-3 alpha + beta (YWHAB))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp YWHAB est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB4062

Détail du produit anti-YWHAB anticorps

Épitope: AA 56-85, N-Term

Homologie: B, Pr, M, Rat

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This YWHAB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 56-85 amino acids from the N-terminal region of human YWHAB.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-YWHAB (ABIN1882154)

Tang, Lv, Sun, Han, Zhou: "14-3-3β Promotes Migration and Invasion of Human Hepatocellular Carcinoma Cells by Modulating Expression of MMP2 and MMP9 through PI3K/Akt/NF-κB Pathway." dans: PLoS ONE, Vol. 11, Issue 1, pp. e0146070, (2016) (PubMed).

Yang, Thein, Wang, Bi, Ericksen, Xu, Han: "BSCL2/seipin regulates adipogenesis through actin cytoskeleton remodelling." dans: Human molecular genetics, Vol. 23, Issue 2, pp. 502-13, (2013) (PubMed).

Yue, Song, Ma, Feng, Guan, Wu, Yang, Jiang, Liu, Cui, Guo: "Effects of triterpenes from Ganoderma lucidum on protein expression profile of HeLa cells." dans: Phytomedicine : international journal of phytotherapy and phytopharmacology, Vol. 17, Issue 8-9, pp. 606-13, (2010) (PubMed).

Komori, Ishizawa, Arai, Hirose, Mizutani, Oda: "Immunoexpression of 14-3-3 proteins in glial cytoplasmic inclusions of multiple system atrophy." dans: Acta neuropathologica, Vol. 106, Issue 1, pp. 66-70, (2003) (PubMed).

Cavet, Lehoux, Berk: "14-3-3beta is a p90 ribosomal S6 kinase (RSK) isoform 1-binding protein that negatively regulates RSK kinase activity." dans: The Journal of biological chemistry, Vol. 278, Issue 20, pp. 18376-83, (2003) (PubMed).

Li, Inoki, Vacratsis, Guan: "The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3." dans: The Journal of biological chemistry, Vol. 278, Issue 16, pp. 13663-71, (2003) (PubMed).

Shumway, Li, Xiong: "14-3-3beta binds to and negatively regulates the tuberous sclerosis complex 2 (TSC2) tumor suppressor gene product, tuberin." dans: The Journal of biological chemistry, Vol. 278, Issue 4, pp. 2089-92, (2003) (PubMed).

Parvaresch, Yesilkaya, Baer, Al-Hasani, Klein: "14-3-3 binding to the IGF-1 receptor is mediated by serine autophosphorylation." dans: FEBS letters, Vol. 532, Issue 3, pp. 357-62, (2002) (PubMed).

Détails sur YWHAB

Antigène: YWHAB (14-3-3 alpha + beta (YWHAB))

Autre désignation: YWHAB

Sujet: YWHAB belongs to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants differing in the 5' UTR, but encoding the same protein, have been identified for the gene. Both variants encode the same protein, however, they are differentially expressed in hematopoietic cells.

Poids moléculaire: 28082

NCBI Accession: NP_003395, NP_647539

UniProt: P31946

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Myometrial Relaxation and Contraction, Maintenance of Protein Location