Sonic Hedgehog anticorps (AA 151-162)

N° du produit ABIN1882186

Cet anticorps Lapin Polyclonal détecte spécifiquement Sonic Hedgehog dans WB. Il présente une réactivité envers Poisson zèbre (Danio rerio) et a été mentionné dans 4+ publications.

Aperçu rapide pour Sonic Hedgehog anticorps (AA 151-162) (ABIN1882186)

Antigène: Sonic Hedgehog (SHH)

Reactivité: Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Sonic Hedgehog est non-conjugé

Application: Western Blotting (WB)

Clone: RB46723

Détail du produit anti-Sonic Hedgehog anticorps

Épitope: AA 151-162

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This shha antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 151-162 amino acids from the Central region of DANRE shha.

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-Sonic Hedgehog (ABIN1882186)

Müller, Chang, Albert, Fischer, Tora, Strähle: "Intronic enhancers control expression of zebrafish sonic hedgehog in floor plate and notochord." dans: Development (Cambridge, England), Vol. 126, Issue 10, pp. 2103-16, (1999) (PubMed).

Zardoya, Abouheif, Meyer: "Evolutionary analyses of hedgehog and Hoxd-10 genes in fish species closely related to the zebrafish." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, Issue 23, pp. 13036-41, (1996) (PubMed).

Ekker, Ungar, Greenstein, von Kessler, Porter, Moon, Beachy: "Patterning activities of vertebrate hedgehog proteins in the developing eye and brain." dans: Current biology : CB, Vol. 5, Issue 8, pp. 944-55, (1995) (PubMed).

Roelink, Augsburger, Heemskerk, Korzh, Norlin, Ruiz i Altaba, Tanabe, Placzek, Edlund, Jessell: "Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord." dans: Cell, Vol. 76, Issue 4, pp. 761-75, (1994) (PubMed).

Détails sur Sonic Hedgehog

Antigène: Sonic Hedgehog (SHH)

Autre désignation: shha

Sujet: Intercellular signal essential for a variety of patterning events during development. Signal produced by the notochord that induces somite patterning, dorso-ventral patterning of the brain and early patterning of the developing eyes. Displays floor plate-inducing activity. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO (By similarity).

Poids moléculaire: 46403

UniProt: Q92008

Pathways: Signalisation Hedgehog, Dopaminergic Neurogenesis, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development