KIT anticorps

N° du produit ABIN1882197

Cet anticorps anti-KIT est un anticorps Souris Monoclonal détectant KIT dans WB, IF et IHC (p). Adapté pour Humain. Ce Primary Antibody a été cité dans 5+ publications.

Aperçu rapide pour KIT anticorps (ABIN1882197)

Antigène: KIT (Mast/stem Cell Growth Factor Receptor (KIT))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp KIT est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 566CT8-5-4

Détail du produit anti-KIT anticorps

Purification: This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.

Immunogène: This KIT Antibody is generated from mouses immunized with human KIT recombinant protein.

Isotype: IgM

Information d'application

Indications d'application: IF: 1:100. IF: 1:10~50. WB: 1:100. IHC-P-Leica: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-KIT (ABIN1882197)

Molderings, Meis, Kolck, Homann, Frieling: "Comparative analysis of mutation of tyrosine kinase kit in mast cells from patients with systemic mast cell activation syndrome and healthy subjects." dans: Immunogenetics, Vol. 62, Issue 11-12, pp. 721-7, (2010) (PubMed).

Cheng, Zhou, Wu, Boriboun, Thorne, Liu, Xiang, Zeng, Tanaka, Tang, Kishore, Tomasson, Miller, Losordo, Qin: "CXCR4-mediated bone marrow progenitor cell maintenance and mobilization are modulated by c-kit activity." dans: Circulation research, Vol. 107, Issue 9, pp. 1083-93, (2010) (PubMed).

Chi, Chen, Zhang, Guo, Wongvipat, Shamu, Fletcher, Dewell, Maki, Zheng, Antonescu, Allis, Sawyers: "ETV1 is a lineage survival factor that cooperates with KIT in gastrointestinal stromal tumours." dans: Nature, Vol. 467, Issue 7317, pp. 849-53, (2010) (PubMed).

Rossi, Gasparotto, Toffolatti, Pastrello, Gallina, Marzotto, Sartor, Barbareschi, Cantaloni, Messerini, Bearzi, Arrigoni, Mazzoleni, Fletcher, Casali, Talamini, Maestro, Maestra, Dei Tos: "Molecular and clinicopathologic characterization of gastrointestinal stromal tumors (GISTs) of small size." dans: The American journal of surgical pathology, Vol. 34, Issue 10, pp. 1480-91, (2010) (PubMed).

Chen, Zong, Zhao, Shi: "Efficacy evaluation of imatinib treatment in patients with gastrointestinal stromal tumors: a meta-analysis." dans: World journal of gastroenterology : WJG, Vol. 16, Issue 33, pp. 4227-32, (2010) (PubMed).

Détails sur KIT

Antigène: KIT (Mast/stem Cell Growth Factor Receptor (KIT))

Autre désignation: KIT

Sujet: This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene.

Poids moléculaire: 109865

NCBI Accession: NP_000213, NP_001087241

UniProt: P10721

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Sensory Perception of Sound, Stem Cell Maintenance, Production of Molecular Mediator of Immune Response, Regulation of long-term Neuronal Synaptic Plasticity