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H2AFX anticorps (N-Term)

H2AFX Reactivité: Humain WB, IHC (p) Hôte: Souris Monoclonal 980CT1-5-5 unconjugated
N° du produit ABIN1882251
  • Antigène Voir toutes H2AFX Anticorps
    H2AFX (H2A Histone Family, Member X (H2AFX))
    Épitope
    • 52
    • 27
    • 18
    • 11
    • 6
    • 5
    • 5
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-30, N-Term
    Reactivité
    • 191
    • 93
    • 60
    • 26
    • 26
    • 20
    • 17
    • 12
    • 9
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    Humain
    Hôte
    • 163
    • 28
    • 2
    Souris
    Clonalité
    • 128
    • 65
    Monoclonal
    Conjugué
    • 123
    • 8
    • 7
    • 7
    • 7
    • 6
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Cet anticorp H2AFX est non-conjugé
    Application
    • 147
    • 53
    • 51
    • 43
    • 36
    • 27
    • 27
    • 25
    • 16
    • 12
    • 8
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Homologie
    Zf, M
    Purification
    This antibody is purified through a protein G column, followed by dialysis against PBS.
    Immunogène
    This H2AFX antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human H2AFX.
    Clone
    980CT1-5-5
    Isotype
    IgG1
    Top Product
    Discover our top product H2AFX Anticorps primaire
  • Indications d'application
    WB: 1:1000. IHC-P: 1:25
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Date de péremption
    6 months
  • Stiff, ODriscoll, Rief, Iwabuchi, Löbrich, Jeggo: "ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation." dans: Cancer research, Vol. 64, Issue 7, pp. 2390-6, (2004) (PubMed).

    Lukas, Melander, Stucki, Falck, Bekker-Jensen, Goldberg, Lerenthal, Jackson, Bartek, Lukas: "Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention." dans: The EMBO journal, Vol. 23, Issue 13, pp. 2674-83, (2004) (PubMed).

    Park, Chan, Park, Oettinger, Kwon: "DNA-PK is activated by nucleosomes and phosphorylates H2AX within the nucleosomes in an acetylation-dependent manner." dans: Nucleic acids research, Vol. 31, Issue 23, pp. 6819-27, (2003) (PubMed).

  • Antigène
    H2AFX (H2A Histone Family, Member X (H2AFX))
    Autre désignation
    H2AFX (H2AFX Produits)
    Synonymes
    anticorps H2A.X, anticorps H2A/X, anticorps H2AX, anticorps AW228881, anticorps H2ax, anticorps Hist5-2ax, anticorps gammaH2ax, anticorps zgc:56329, anticorps h2a.x, anticorps h2a/x, anticorps h2ax, anticorps RGD1566119, anticorps h2a, anticorps h2afx, anticorps H2A histone family member X, anticorps H2A histone family, member X, anticorps H2A histone family member X L homeolog, anticorps histone cluster 1, H2ah, anticorps histone cluster 2, H2ab S homeolog, anticorps histone H2AX, anticorps H2AFX, anticorps H2afx, anticorps h2afx, anticorps h2afx.L, anticorps HIST1H2AH, anticorps hist2h2ab.S, anticorps LOC100522201, anticorps LOC100720536
    Sujet
    Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.
    Poids moléculaire
    15145
    NCBI Accession
    NP_002096
    UniProt
    P16104
    Pathways
    Telomere Maintenance, Réparation de l'ADN, Positive Regulation of Response to DNA Damage Stimulus
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