E2F1 anticorps (AA 133-322)

N° du produit ABIN1886014

Cet anticorps Lapin Polyclonal détecte spécifiquement E2F1 dans WB et IF. Il présente une réactivité envers Humain.

Aperçu rapide pour E2F1 anticorps (AA 133-322) (ABIN1886014)

Antigène: E2F1 (E2F Transcription Factor 1 (E2F1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp E2F1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Détail du produit anti-E2F1 anticorps

Épitope: AA 133-322

Purification: Purified by antigen-affinity chromatography.

Immunogène: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 133 and 322 (Q01094) of E2F1

Information d'application

Indications d'application: Suggested dilutions:
Western blotting: 1.500-1.3000
Immunofluorescence: 1.100-1.200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: Biohazard Informations: This product contains thimerosal which is hazardous.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Détails sur E2F1

Antigène: E2F1 (E2F Transcription Factor 1 (E2F1))

Autre désignation: E2F1

Sujet: The protein encoded by this gene is a member of the E2F family of transcription factors.The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses.The E2F proteins contain several evolutionally conserved domains found in most members of the family.These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain.This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain.This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner.It can mediate both cell proliferation and p53-dependent/independent apoptosis.[provided by RefSeq]

Poids moléculaire: 47 kDa

ID gène: 1869

NCBI Accession: NM_005225, NP_005216

Pathways: Signalisation p53, Cycle Cellulaire, Mitotic G1-G1/S Phases, DNA Replication, M Phase, Autophagy