Lamin A/C anticorps (AA 59-259)

N° du produit ABIN1886567

L’anticorps Lapin Polyclonal anti-Lamin A/C a été validé pour WB et IHC. Il convient pour détecter Lamin A/C dans des échantillons de Humain.

Aperçu rapide pour Lamin A/C anticorps (AA 59-259) (ABIN1886567)

Antigène: Lamin A/C (LMNA)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Lamin A/C est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-Lamin A/C anticorps

Épitope: AA 59-259

Purification: Purified by antigen-affinity chromatography.

Immunogène: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 59 and 259 of Lamin A/C

Information d'application

Indications d'application: Suggested dilutions:
Western blotting: 1.500-1.3000
Immunohistochemistry: 1.100-1.250

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: Biohazard Informations: This product contains thimerosal which is hazardous.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Détails sur Lamin A/C

Antigène: Lamin A/C (LMNA)

Autre désignation: Lamin A/C

Sujet: The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane.The lamin family of proteins make up the matrix and are highly conserved in evolution.During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated.Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression.Vertebrate lamins consist of two types, A and B.Through alternate splicing, this gene encodes three type A lamin isoforms.Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.[provided by RefSeq]

Poids moléculaire: 65 kDa

ID gène: 4000

NCBI Accession: NP_005563, NM_005572

Pathways: Apoptose, Caspase Cascade in Apoptosis, ER-Nucleus Signaling, Protein targeting to Nucleus