NAPA anticorps (AA 78-269)

N° du produit ABIN1886662

Cet anticorps Lapin Polyclonal détecte spécifiquement NAPA dans WB et IF. Il présente une réactivité envers Humain.

Aperçu rapide pour NAPA anticorps (AA 78-269) (ABIN1886662)

Antigène: NAPA (N-Ethylmaleimide-Sensitive Factor Attachment Protein, alpha (NAPA))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NAPA est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Détail du produit anti-NAPA anticorps

Épitope: AA 78-269

Purification: Purified by antigen-affinity chromatography.

Immunogène: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 78 and 269 of Human NAPA

Information d'application

Indications d'application: Suggested dilutions:
Western blotting: 1.500-1.3000
Immunofluorescence: 1.100-1.200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: Biohazard Informations: This product contains thimerosal which is hazardous.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Détails sur NAPA

Antigène: NAPA (N-Ethylmaleimide-Sensitive Factor Attachment Protein, alpha (NAPA))

Autre désignation: alpha SNAP

Sujet: The 'SNARE hypothesis' is a model explaining the process of docking and fusion of vesicles to their target membranes.According to this model, membrane proteins from the vesicle (v-SNAREs) and proteins from the target membrane (t-SNAREs) govern theof vesicle targeting and docking through mutual recognition.Once the 2 classes of SNAREs bind to each other, they form a complex that recruits the general elements of the fusion apparatus, namely NSF (N-ethylmaleimide-sensitive factor) and SNAPs (soluble NSF-attachment proteins), to the site of membrane fusion, thereby forming the 20S fusion complex.Alpha- and gamma-SNAP are found in a wide range of tissues and act synergistically in intra-Golgi transport.The sequence of the predicted 295-amino acid human protein encoded by NAPA shares 37%, 60%, and 67% identity with the sequences of yeast, Drosophila, and squid alpha-SNAP, respectively.Platelets contain some of the same proteins, including NSF, p115/TAP, alpha-SNAP, gamma-SNAP, and the t-SNAREs syntaxin-2 and syntaxin-4, that are used in many vesicular transport processes in other cell types.Platelet exocytosis uses a molecular mechanism similar to that used by other secretory cells, such as neurons, although the proteins used by the platelet and their modes of regulation may be quite different.[provided by RefSeq]

Poids moléculaire: 33 kDa

ID gène: 8775

NCBI Accession: NM_003827, NP_003818

Pathways: Synaptic Vesicle Exocytosis, Asymmetric Protein Localization