RRM2B anticorps (AA 2-17)

N° du produit ABIN1886848

Cet anticorps Lapin Polyclonal détecte spécifiquement RRM2B dans WB, ELISA et IHC. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour RRM2B anticorps (AA 2-17) (ABIN1886848)

Antigène: RRM2B (Ribonucleotide Reductase M2 B (TP53 Inducible) (RRM2B))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RRM2B est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Détail du produit anti-RRM2B anticorps

Épitope: AA 2-17

Purification: Affinity chromatography purified via peptide column

Immunogène: Synthetic peptide corresponding to amino acids 2 to 17 of human p53R2.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Conseil sur la manipulation: Avoid freezing and thawing repeatly.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Détails sur RRM2B

Antigène: RRM2B (Ribonucleotide Reductase M2 B (TP53 Inducible) (RRM2B))

Autre désignation: p53R2

Sujet: The p53 tumor-suppressor gene integrates numerous signals that control cell life and death.Several novel molecules involved in p53 signaling, including p53R2 , Chk2, p53AIP1, Noxa, PIDD, and PID/MTA2, were recently discovered.p53R2 is a p53 inducible gene that contains a p53 binding sequence and encodes a subunit of the enzyme ribonucleotide reductase.p53R2 is induced by the reagents, ultraviolet and gamma-irradiation that cause DNA damages.The product of p53R2 gene is directly involved in the p53 checkpoint for repair of damaged DNA.The isoform of the p53 family member p73 also induces p53R2 expression.p53R2 is an important target of p53 for tumor suppression.

Poids moléculaire: 39 kDa

Pathways: Signalisation p53, Negative Regulation of intrinsic apoptotic Signaling