MTA2 anticorps (AA 652-668)

N° du produit ABIN1886893

Cet anticorps Lapin Polyclonal détecte spécifiquement MTA2 dans WB, ELISA et ICC. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour MTA2 anticorps (AA 652-668) (ABIN1886893)

Antigène: MTA2 (Metastasis Associated 1 Family, Member 2 (MTA2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MTA2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Détail du produit anti-MTA2 anticorps

Épitope: AA 652-668

Réactivité croisée (Details): No cross response to MTA1.

Purification: Purified by DEAE column

Immunogène: Synthetic peptide corresponding to amino acids 652 to 668 of human PID (6), which differ from the mouse sequence by one amino acid.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Conseil sur la manipulation: Avoid freezing and thawing repeatly.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Détails sur MTA2

Antigène: MTA2 (Metastasis Associated 1 Family, Member 2 (MTA2))

Autre désignation: PID

Sujet: The p53 tumor-suppressor gene integrates numerous signals that control cell life and death.Several novel molecules involved in p53 pathway, including Chk2, p53R2, p53AIP1, Noxa, PIDD, and PID/MTA2, were recently discovered.The transcriptional activity of p53 is modulated by protein stability and acetylation.PID/MTA2, also termed MTA1-L1, was found to be a subunit of nucleosome remodeling and deacetylating (NRD/NuRD) complex.PID/MTA2 modulates the enzymatic activity of the histone deacetylase complex and its expression reduces the levels of acetylated p53.Deacetylation of p53 by PID/MTA2 represses p53-dependent transcriptional activation and modulates p53-mediated cell growth arrest and apoptosis.PID/MTA2 is ubiquitously expressed in human tissues.
Synonyms: PID, MTA2

Poids moléculaire: 75 kDa

Pathways: Chromatin Binding