MAP3K14 anticorps (AA 931-947)

N° du produit ABIN1886903

Détail du produit anti-MAP3K14 anticorps

Antigène: MAP3K14 (Mitogen-Activated Protein Kinase Kinase Kinase 14 (MAP3K14))

Épitope: AA 931-947

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAP3K14 est non-conjugé

Application: Western Blotting (WB), ELISA

Purification: Purified by DEAE column

Immunogène: Peptide corresponding to amino acids 931 to 947 of human NIK.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Conseil sur la manipulation: Avoid freezing and thawing repeatly.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Détails sur MAP3K14

Antigène: MAP3K14 (Mitogen-Activated Protein Kinase Kinase Kinase 14 (MAP3K14))

Autre désignation: NIK (MAP3K14 Produits)

Synonymes: anticorps FTDCR1B, anticorps HS, anticorps HSNIK, anticorps NIK, anticorps F23F1.4, anticorps F23F1_4, anticorps mitogen-activated protein kinase kinase kinase 14, anticorps Nik, anticorps aly, anticorps mitogen-activated protein kinase kinase kinase 14, anticorps MAP3K14, anticorps Map3k14, anticorps MAPKKK14

Sujet: Nuclear factor kappa B (NF-kappaB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses.NF-kappaB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFalpha, LPS and mitogens.A serine/threonine protein kinase which mediates NF-kappaB activation by IL-1, TNFalpha and CD95 was identified recently and designated NIK (for NF-kappaB inducing kinase).NIK is an activator of IkappaB kinase alpha and beta (IKKalpha and IKKbeta).Therefore, NIK is a key molecule in the NF-kappaB signaling pathway leading to the induction of a variety of gene expression in response to proinflammatory cytokines and bacteria products.

UniProt: Q99558

Pathways: Signalisation NF-kappaB, TCR Signaling