FAS anticorps

N° du produit ABIN1944804

Cet anticorps anti-FAS est un anticorps Lapin Polyclonal détectant FAS dans WB et IHC. Adapté pour Humain. Ce Primary Antibody a été cité dans 4+ publications.

Aperçu rapide pour FAS anticorps (ABIN1944804)

Antigène: FAS (TNF Receptor Superfamily, Member 6 (FAS))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FAS est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-FAS anticorps

Isotype: IgG1

Information d'application

Indications d'application: WB: 1:1000. IHC: 1:50-1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Stock: 4 °C,-20 °C

Références pour anticorps anti-FAS (ABIN1944804)

Cascino, Papoff, De Maria, Testi, Ruberti: "Fas/Apo-1 (CD95) receptor lacking the intracytoplasmic signaling domain protects tumor cells from Fas-mediated apoptosis." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 156, Issue 1, pp. 13-7, (1996) (PubMed).

Liu, Cheng, Mountz: "Differential expression of human Fas mRNA species upon peripheral blood mononuclear cell activation." dans: The Biochemical journal, Vol. 310 ( Pt 3), pp. 957-63, (1995) (PubMed).

Cascino, Fiucci, Papoff, Ruberti: "Three functional soluble forms of the human apoptosis-inducing Fas molecule are produced by alternative splicing." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 154, Issue 6, pp. 2706-13, (1995) (PubMed).

Oehm, Behrmann, Falk, Pawlita, Maier, Klas, Li-Weber, Richards, Dhein, Trauth: "Purification and molecular cloning of the APO-1 cell surface antigen, a member of the tumor necrosis factor/nerve growth factor receptor superfamily. Sequence identity with the Fas antigen." dans: The Journal of biological chemistry, Vol. 267, Issue 15, pp. 10709-15, (1992) (PubMed).

Détails sur FAS

Antigène: FAS (TNF Receptor Superfamily, Member 6 (FAS))

Autre désignation: FAS

Sujet: Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death- inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS- mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).

Poids moléculaire: 37732 Da

ID gène: 355

UniProt: P25445

Pathways: Signalisation p53, Apoptose, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity