CD74 anticorps (AA 1-232)

N° du produit ABIN1944838

Cet anticorps Souris Monoclonal détecte spécifiquement CD74 dans FACS et WB. Il présente une réactivité envers Humain et a été mentionné dans 4+ publications.

Aperçu rapide pour CD74 anticorps (AA 1-232) (ABIN1944838)

Antigène: CD74 (HLA-DR-gamma (CD74))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD74 est non-conjugé

Application: Flow Cytometry (FACS), Western Blotting (WB)

Clone: 1267CT820-116-140-154

Détail du produit anti-CD74 anticorps

Épitope: AA 1-232

Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogène: This antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 1-232 amino acids from human.

Isotype: IgG2b kappa

Information d'application

Indications d'application: WB: 1:1000. FC: 1:25

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-CD74 (ABIN1944838)

Kudo, Chao, Narni, Saunders: "Structure of the human gene encoding the invariant gamma-chain of class II histocompatibility antigens." dans: Nucleic acids research, Vol. 13, Issue 24, pp. 8827-41, (1986) (PubMed).

OSullivan, Larhammar, Wilson, Peterson, Quaranta: "Structure of the human Ia-associated invariant (gamma)-chain gene: identification of 5' sequences shared with major histocompatibility complex class II genes." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 83, Issue 12, pp. 4484-8, (1986) (PubMed).

Claesson, Larhammar, Rask, Peterson: "cDNA clone for the human invariant gamma chain of class II histocompatibility antigens and its implications for the protein structure." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 80, Issue 24, pp. 7395-9, (1984) (PubMed).

Strubin, Mach, Long: "The complete sequence of the mRNA for the HLA-DR-associated invariant chain reveals a polypeptide with an unusual transmembrane polarity." dans: The EMBO journal, Vol. 3, Issue 4, pp. 869-72, (1984) (PubMed).

Détails sur CD74

Antigène: CD74 (HLA-DR-gamma (CD74))

Autre désignation: CD74

Sujet: Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.

Poids moléculaire: 33516

ID gène: 972

UniProt: P04233

Pathways: Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Negative Regulation of intrinsic apoptotic Signaling, Cancer Immune Checkpoints