ErbB2/Her2 anticorps (pSer1107)

N° du produit ABIN1944841

Cet anticorps Lapin Polyclonal détecte spécifiquement ErbB2/Her2 dans WB et DB. Il présente une réactivité envers Humain et a été mentionné dans 3+ publications.

Aperçu rapide pour ErbB2/Her2 anticorps (pSer1107) (ABIN1944841)

Antigène: ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ErbB2/Her2 est non-conjugé

Application: Western Blotting (WB), Dot Blot (DB)

Clone: RB40102

Détail du produit anti-ErbB2/Her2 anticorps

Épitope: pSer1107

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This ERBB2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S1107 of human ERBB2.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. DB: 1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-ErbB2/Her2 (ABIN1944841)

Geradts, Bean, Bentley, Barry: "The oncotype DX recurrence score is correlated with a composite index including routinely reported pathobiologic features." dans: Cancer investigation, Vol. 28, Issue 9, pp. 969-77, (2010) (PubMed).

Zaoui, Benseddik, Daou, Salaün, Badache: "ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 43, pp. 18517-22, (2010) (PubMed).

Stackievicz, Paran, Bernheim, Shapira, Weisenberg, Kaufman, Klein, Gutman: "Prognostic significance of HER-2/neu expression in patients with ductal carcinoma in situ." dans: The Israel Medical Association journal : IMAJ, Vol. 12, Issue 5, pp. 290-5, (2010) (PubMed).

Détails sur ErbB2/Her2

Antigène: ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

Autre désignation: ERBB2

Sujet: This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.

Poids moléculaire: 137910

ID gène: 2064

NCBI Accession: NP_001005862, NP_004439

UniProt: P04626

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Skeletal Muscle Fiber Development