Nibrin anticorps (Ser343)

N° du produit ABIN197200

Cet anticorps Lapin Polyclonal détecte spécifiquement Nibrin dans WB. Il présente une réactivité envers Humain.

Aperçu rapide pour Nibrin anticorps (Ser343) (ABIN197200)

Antigène: Nibrin (NBN)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Nibrin est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Nibrin anticorps

Épitope: Ser343

Specificité: This antibody detects endogenous levels of total p95/NBS1 protein.

Purification: Affinity Chromatography using epitope-specific immunogen.

Immunogène: The antiserum was produced against synthesized non-phosphopeptide derived from human p95/NBS1 around the phosphorylation site of Serine 343 (S-L-SP-Q-G).

Information d'application

Indications d'application: Western Blot: 1/100approx. 1/500. Immunohistochemistry: 1/50approx. 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS (without Mg2+ and Ca2+), pH 7.4 containing 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody (in aliquots) at -20 °C.

Détails sur Nibrin

Antigène: Nibrin (NBN)

Autre désignation: Nibrin

Sujet: The p95 gene (also known as NBS1 and Nibrin) is a member of the hMre11/hRad50 double-strand break complex (MRN complex). This protein complex has been implicated in Nijmegen breakage syndrome, an autosomal recessive disorder marked by increased cancer incidence, cell cycle checkpoint deficits, and ionizing radiation sensitivity, thus revealing a direct molecular link between double-strand break repair and cell cycle checkpoint functions. In case of infection by adenovirus E4, the MRN complex is inactivated and degraded by viral oncoproteins, thereby preventing concatenation of viral genomes in infected cells. NBS1 is expressed ubiquitously and presents high levels in testis.Synonyms: Cell cycle regulatory protein p95, NBN, NBS, NBS1, Nijmegen breakage syndrome protein 1, P95

ID gène: 4683

NCBI Accession: NP_002476

UniProt: O60934

Pathways: Réparation de l'ADN, Production of Molecular Mediator of Immune Response