Clusterin anticorps

N° du produit ABIN205727

L’anticorps anti-Clusterin Polyclonal Lapin est utilisé pour la détection de Clusterin dans des échantillons de Humain. Il a été validé pour WB.

Aperçu rapide pour Clusterin anticorps (ABIN205727)

Antigène: Clusterin (CLU)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Clusterin est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Clusterin anticorps

Specificité: Recognizes human clusterin, also known as apolipoprotein J, Ku70-binding protein 1 or TRPM-2. Clusterin is a ubiquitous glycoprotein which exists in at least two distinct isoforms, a proapoptotic nuclear form, of 49kD, and a prosurvival secretory form with a molecular weight of 75-80kD. Clusterin is implicated in several diverse physiological processes including sperm maturation, cell differentiation, and apoptosis. Clusterin upregulation has been reported in various human malignancies, including bladder, prostate, and breast tumors. Following specific stress induced injury, secretory clusterin acts as a molecular chaperone, scavenging denatured proteins outside cells. It has been shown to be upregulated in Alzheimer's€™s disease (Chen et al. 2012), retinitis pigmentosa (Jobes et al 1993), glomerulonephritis, atherosclerosis and myocardial infarction (Rosenberg et al. 2002).

Purification: Purified

Immunogène: Recombinant human clusterin isoform 1.

Type of Immunogen: Recombinant protein

Isotype: IgG

Information d'application

Indications d'application: Approved: WB (0.5 - 1 μg/mL)

Usage: Western Blot: LS-C42331 detects a band of approximately 60kD in human brain tissue lysate.

Commentaires:

Target Species of Antibody: Human

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: PBS, 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Détails sur Clusterin

Antigène: Clusterin (CLU)

Autre désignation: CLU / Clusterin

Sujet: Name/Gene ID: CLU

Synonyms: CLU, APO-J, Apolipoprotein J, CLU1, Clusterin, Complement lysis inhibitor, CLI, AAG4, Aging-associated protein 4, Ku70-binding protein 1, KUB1, SGP2, APOJ, SGP-2, Sulfated glycoprotein 2, CLU2, Complement cytolysis inhibitor, NA1/NA2, SP-40

ID gène: 1191

UniProt: P10909

Pathways: Apoptose, Negative Regulation of intrinsic apoptotic Signaling