C5 anticorps (N-Term)

N° du produit ABIN206662

Cet anticorps Souris Monoclonal détecte spécifiquement C5 dans WB, ELISA et Func. Il présente une réactivité envers Humain.

Aperçu rapide pour C5 anticorps (N-Term) (ABIN206662)

Antigène: C5 (Complement Component 5 (C5))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp C5 est non-conjugé

Application: Western Blotting (WB), ELISA, Functional Studies (Func)

Clone: 046-10-2-2 (10-04)

Détail du produit anti-C5 anticorps

Épitope: N-Term

Specificité: Recognizes secreted complement component 5 (C5), a 190kD serine protease present in blood serum. It is composed of an 115kD disulphide linked alpha-chain and a 75 kD beta-chain. In addition to its role in complement, C5 is thought to be associated with inflammation, stimulating tumor necrosis factor alpha, interferon gamma mediated suppression of IL10 and IL12 production. C5 is activated via either the classical or the alternative complement pathway, by proteolytic cleavage of C5a from the N-terminal of the alpha-chain, by C5 convertase. C5a is an anaphylatoxin which mediates local inflammation. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. It also stimulates chemotaxis of neutrophils, eosinophils, basophils and monocytes towards the site of inflammation. The remaining fragment, C5b, initiates the assembly of the membrane attack complex. In hemolysis inhibition studies it was found that Will block C5 hemolytic activity. Removal of sodium azide is recommended prior to use in functional assays. XXX XXX recommend the use of EUQOO3 for this purpose.

Purification: Protein A purified

Immunogène: Purified human C5.

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

Target Species of Antibody: Human

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Borate buffered saline, 0.1 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.

Détails sur C5

Antigène: C5 (Complement Component 5 (C5))

Autre désignation: Complement C5

Sujet: Name/Gene ID: C5

Synonyms: C5, Anaphylatoxin C5a analog, CPAMD4, Complement C5, Complement component 5

ID gène: 727

UniProt: P01031

Pathways: Système du Complément, Carbohydrate Homeostasis