CD74 anticorps (C-Term)

N° du produit ABIN211740

Cet anticorps anti-CD74 est un anticorps Souris Monoclonal détectant CD74 dans FACS, IHC, IP, IHC (p) et IHC (fro). Adapté pour Humain.

Aperçu rapide pour CD74 anticorps (C-Term) (ABIN211740)

Antigène: CD74 (HLA-DR-gamma (CD74))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD74 est non-conjugé

Application: Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: BU45

Détail du produit anti-CD74 anticorps

Épitope: C-Term

Specificité: Recognizes human CD74, a type II transmembrane protein, which is also known as the MHC class II associated invariant chain. The Recognizes 33, 35 and 41 kD isoforms of CD74. The CD74 Molecule plays a critical role in the presentation of peptides, by the MHC class II antigens, to CD4 positive lymphocytes. CD74 is expressed on MHC class II positive cells including B cells, a subset of activated T cells, monocytes, dendritic cells and by various types of carcinoma. Expression of CD74 is primarily intracellular with moderate expression at the cell surface of B cells and monocytes. The Bu45 antibody binds to an epitope within the extracytoplasmic domain of the CD74 Molecule, which is distal from the C-terminus. *Membrane permeabilization may enhance CD74 staining. XXX recommend the use of Leucoperm (product code BUF09) for this purpose.

Purification: Protein G purified

Immunogène: B lymphoblastoid cell line HFB1.

Type of Immunogen: Cells

Isotype: IgG1

Information d'application

Indications d'application: Approved: Flo (1:25 - 1:50), IHC, IHC-Fr, IHC-P, IP

Usage: Flow Cytometry: Use 10 μL of the suggested working dilution to label 1x10^6 cells in 100 μL. Method sheets are available on request.

Commentaires:

Target Species of Antibody: Human

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: PBS,  pH 7.4, 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Détails sur CD74

Antigène: CD74 (HLA-DR-gamma (CD74))

Autre désignation: CD74 / CLIP

Sujet: Name/Gene ID: CD74

Synonyms: CD74, CD74 antigen, DHLAG, HLADG, HLA-DR-gamma, Ia-associated invariant chain, p33, MHC HLA-DR gamma chain, Ia-GAMMA

ID gène: 972

UniProt: P04233

Pathways: Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Negative Regulation of intrinsic apoptotic Signaling, Cancer Immune Checkpoints