CD59 anticorps

N° du produit ABIN2191998

Cet anticorps anti-CD59 est un anticorps Souris Monoclonal détectant CD59 dans WB, FACS, IP et Inhibition. Adapté pour Humain. Ce Primary Antibody a été cité dans 1 publication.

Aperçu rapide pour CD59 anticorps (ABIN2191998)

Antigène: CD59

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD59 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP), Blocking Antibody (Inhibition)

Clone: MEM-43

Détail du produit anti-CD59 anticorps

Stérilité: 0.2 μm filtered

niveau d'endotoxine: Low endotoxin level

Information d'application

Indications d'application: For flow cytometry and Western blotting dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:10. For neutralization of biological activity dilutions have to be made according to the amounts endotoxin to be inactivated.

Restrictions: For Research Use only

Stockage

Buffer: PBS and 0.1 % bovine serum albumin with low endotoxin level.

Stock: 4 °C

Stockage commentaire: Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.

Date de péremption: 12 months

Références pour anticorps anti-CD59 (ABIN2191998)

Yamamoto, Nakane, Doi, Osaki: "Lipopolysaccharide signal transduction in oral keratinocytes--involvement of CD59 but not CD14." dans: Cellular signalling, Vol. 15, Issue 9, pp. 861-9, (2003) (PubMed).

Détails sur CD59

Antigène: CD59

Autre désignation: CD59

Sujet: The antibody is the prototypic antibody for the CD59 determinant, a PI-linked glycoprotein of 18-25 kDa, which is broadly expressed on most types of cells. The antigen is the major complement-protecting molecule of human cells. It is expressed on all leukocytes, erythrocytes and most other cell types. Binding of this antibody inhibits the complement-protecting activity of CD59. CD59 is one of the complement regulatory membrane proteins that is missing in Paroxysmal Nocturnal Haemoglobinuria (PNH). Anti CD59 reagents may be useful in the differential diagnosis of PNH type II and PNH type I. Recently a role for CD59 in LPS signal transduction has been reported in keratinocytes. The antibody reacts with well defined epitope (W40, R-53) on CD59 Molecule.

Pathways: Système du Complément