GDF15 anticorps (N-Term)

N° du produit ABIN238331

L’anticorps Souris Monoclonal anti-GDF15 a été validé pour FACS et cELISA. Il convient pour détecter GDF15 dans des échantillons de Humain.

Aperçu rapide pour GDF15 anticorps (N-Term) (ABIN238331)

Antigène: GDF15 (Growth Differentiation Factor 15 (GDF15))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp GDF15 est non-conjugé

Application: Flow Cytometry (FACS), Cell-ELISA (cELISA)

Clone: ME-6D10

Détail du produit anti-GDF15 anticorps

Épitope: AA 30-194, N-Term

Purification: Protein G

Immunogène: genetic immunisation with cDNA encoding aa30-194 (N-term) of MIC-1 proprotein

Isotype: IgG1

Information d'application

Indications d'application: Flow cytometry: 1.2 µg/10^6 cells
CELISA: 1:200 - 1:400
For each application a titration should be performed to determine the optimal concentration.

Commentaires:

Synonyms: GDF15

Restrictions: For Research Use only

Stockage

Buffer: PBS, pH 7.2

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C

Stockage commentaire: short term: 2 °C - 8 °C, long term: -20 °C

Détails sur GDF15

Antigène: GDF15 (Growth Differentiation Factor 15 (GDF15))

Autre désignation: MIC-1

Sujet: Macrophage inhibitory cytokine-1 (MIC-1) is a member of the transforming growth factor-ß superfamily that regulates a wide variety of physiological processes involved in tissue differentiation and maintenance. MIC-1 is synthesized as a 62-kDa intracellular protein, which, after cleavage by a furin like protease, is secreted as a 25-kDa disulphide-linked dimeric protein. Expression of MIC-1 results in inhibition of macrophage activation, regulated by the p53 pathway, in response to pro-inflammatory monokines. MIC-1 is involved in tumour pathogenesis and its measurement can be used as a clinical tool for the diagnosis of a wide range of cancers. It could be a useful marker for aggressive prostate cancer while MIC-1 is upregulated in advanced and more aggressive prostatic tumours.

UniProt: Q99988

Pathways: SARS-CoV-2 Protein Interactome