GDF15 anticorps (N-Term)
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- Antigène Voir toutes GDF15 Anticorps
- GDF15 (Growth Differentiation Factor 15 (GDF15))
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Épitope
- AA 30-194, N-Term
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp GDF15 est non-conjugé
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Application
- Flow Cytometry (FACS), Cell-ELISA (cELISA)
- Purification
- Protein G
- Immunogène
- genetic immunisation with cDNA encoding aa30-194 (N-term) of MIC-1 proprotein
- Clone
- ME-6D10
- Isotype
- IgG1
- Top Product
- Discover our top product GDF15 Anticorps primaire
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- Indications d'application
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Flow cytometry: 1.2 µg/10^6 cells
CELISA: 1:200 - 1:400
For each application a titration should be performed to determine the optimal concentration. - Commentaires
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Synonyms: GDF15
- Restrictions
- For Research Use only
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- Buffer
- PBS, pH 7.2
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C
- Stockage commentaire
- short term: 2 °C - 8 °C, long term: -20 °C
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- Antigène
- GDF15 (Growth Differentiation Factor 15 (GDF15))
- Autre désignation
- MIC-1 (GDF15 Produits)
- Synonymes
- anticorps GDF15, anticorps GDF-15, anticorps MIC-1, anticorps MIC1, anticorps NAG-1, anticorps PDF, anticorps PLAB, anticorps PTGFB, anticorps SBF, anticorps growth differentiation factor 15, anticorps GDF15, anticorps Gdf15
- Sujet
- Macrophage inhibitory cytokine-1 (MIC-1) is a member of the transforming growth factor-ß superfamily that regulates a wide variety of physiological processes involved in tissue differentiation and maintenance. MIC-1 is synthesized as a 62-kDa intracellular protein, which, after cleavage by a furin like protease, is secreted as a 25-kDa disulphide-linked dimeric protein. Expression of MIC-1 results in inhibition of macrophage activation, regulated by the p53 pathway, in response to pro-inflammatory monokines. MIC-1 is involved in tumour pathogenesis and its measurement can be used as a clinical tool for the diagnosis of a wide range of cancers. It could be a useful marker for aggressive prostate cancer while MIC-1 is upregulated in advanced and more aggressive prostatic tumours.
- UniProt
- Q99988
- Pathways
- SARS-CoV-2 Protein Interactome
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