LDLR anticorps (C-Term)

N° du produit ABIN2443758

Cet anticorps anti-LDLR Polyclonal Lapin (ABIN2443758) détecte spécifiquement LDLR dans WB. L’anticorps est réactif avec des échantillons de Rat.

Aperçu rapide pour LDLR anticorps (C-Term) (ABIN2443758)

Antigène: LDLR (Low Density Lipoprotein Receptor (LDLR))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LDLR est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-LDLR anticorps

Épitope: C-Term

Fonction: Low density lipoprotein receptor LDLR Rabbit Polyclonal Antibody

Specificité: Specifically recognizes the LDL receptor at a molecular weight of 160 kDa. The antibody recognizes the C-terminal portion of LDLR.

Immunogène: C-terminal peptide

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: If reconstituted with deionized water in 100 μL: WB: 1:1500. Optimal dilution has to be determined by the user.

Buffer: Lyophilized serum

Agent conservateur: Without preservative

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Lyophilized antibodies can be kept at 4°C for up to 3 months and should be kept at -20°C for long-term storage (2 years). To avoid freeze-thaw cycles, reconstituted antibodies should be aliquoted before freezing for long-term (1 year) storage (-80°C) or kept at 4°C for short-term usage (2 months). For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made with the assay buffer. After the maximum long-term storage period (2 years lyophilized or 1 year reconstituted) antibodies should be tested in your assay with a standard sample to verify if you have noticed any decrease in their efficacy. To limit antibody loss or degradation, BSA (final concentration 1%) and sodium azide (final concentration 0.02%) can be added to the suggested first dilution. It is important to first verify if those preservatives are compatible with your assay.

Date de péremption: 24 months

Détails sur LDLR

Antigène: LDLR (Low Density Lipoprotein Receptor (LDLR))

Autre désignation: Low density lipoprotein receptor LDLR

Sujet:

LDL receptor

The LDL Receptor (LDLR) is a transmembrane protein of 839 amino acids that mediates the endocytosis of cholesterol-rich LDL. The LDL receptor plays a critical role in cholesterol homeostasis. It binds, internalizes, and removes LDL from serum. LDLR recognizes the apoprotein B100 which is embedded in the phospholipid outer layer of LDL particles, as well as the apoE protein found in chylomicron remnants and VLDL remnants (IDL). To be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits (or buds) on the cell surface. Defects in LDLR are the cause of familial hypercholesterolemia, a common autosomal semi-dominant disease that affects about 1 in 500 individuals.

UniProt: P35952

Pathways: Hepatitis C, Lipid Metabolism