RMI1 anticorps

N° du produit ABIN2459011

Détail du produit anti-RMI1 anticorps

Antigène: RMI1 (Homolog of Yeast RecQ-mediated Genome Instability 1 (RMI1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RMI1 est non-conjugé

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogène: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human RMI1.

Information d'application

Indications d'application: RMI1 antibody can be used for detection of RMI1 by ELISA at 1:1562500. RMI1 antibody can be used for detection of RMI1 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Conseil sur la manipulation: As with any antibody avoid repeat freeze-thaw cycles.

Stock: 4 °C/-20 °C

Stockage commentaire: For short periods of storage (days) store at 4 °C. For longer periods of storage, store RMI1 antibody at -20 °C.

Détails sur RMI1

Antigène: RMI1 (Homolog of Yeast RecQ-mediated Genome Instability 1 (RMI1))

Autre désignation: RMI1 (RMI1 Produits)

Synonymes: anticorps BLAP75, anticorps C9orf76, anticorps FAAP75, anticorps RP11-346I8.1, anticorps RGD1310671, anticorps 4932432N11Rik, anticorps C79893, anticorps MGC55882, anticorps zgc:55882, anticorps RecQ mediated genome instability 1, anticorps RecQ mediated genome instability 1 L homeolog, anticorps RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae), anticorps RMI1, anticorps Rmi1, anticorps rmi1.L, anticorps rmi1

Sujet: RMI1 is an essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. RMI1 promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. RMI1 is required for BLM phosphorylation during mitosis. Within the BLM complex, RMI1 is required for BLM and TOP3A stability.RMI1 is a component of protein complexes that limit DNA crossover formation via the dissolution of double Holliday junctions (Raynard et al., 2006 [PubMed 16595695]).

Poids moléculaire: 70 kDa

ID gène: 80010

NCBI Accession: NP_079221

UniProt: Q9H9A7

Pathways: Réparation de l'ADN