TRIM5 anticorps (truncated)

N° du produit ABIN2464117

Détail du produit anti-TRIM5 anticorps

Antigène: TRIM5 (Tripartite Motif Containing 5 (TRIM5))

Épitope: truncated

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TRIM5 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Immunogène: Ni-NTA purified truncated recombinant human trim5 alpha expressed in E. Coli strain BL21 (DE3).

Clone: 3B11H2

Isotype: IgG1

Information d'application

Indications d'application: Western Blot:Dilution 1:1,000 - 1:5,000
IHC(P):Dilution 1:100 - 1:400
IHC(F):Dilution 1:200 - 1:400
Determining optimal working dilutions by titration test.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Stock: -20 °C

Stockage commentaire: Trim5? monoclonal antibody can be stored at -20 °C, stable for one year.

Détails sur TRIM5

Antigène: TRIM5 (Tripartite Motif Containing 5 (TRIM5))

Autre désignation: Trim5a (TRIM5 Produits)

Synonymes: anticorps TRIM5, anticorps RNF88, anticorps TRIM5alpha, anticorps EG667823, anticorps Gm8833, anticorps RGD1304579, anticorps tripartite motif containing 5, anticorps tripartite motif-containing 5, anticorps TRIM5, anticorps Trim5

Sujet: TRIM5-alpha is a protein that is found in the cells of many mammals and fends of various retrovirus infections. It protects monkeys from infection with HIV-1, and humans from infection with some other viruses. If a retrovirus has entered a cell, it needs to shed its capsid in order to reversely transcribe its genes, so that they can be expressed by the host cell. It is believed that TRIM5alpha, which is present in the cytoplasm, somehow recognizes the capsid and blocks its shedding, thereby stopping the virus in its tracks. It thus represents an intracellular defense completely separate from the rest of the body's immune system.

ID gène: 85364

UniProt: Q9NUD5

Pathways: Activation of Innate immune Response