JAG1 anticorps (AA 110-125)
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- Antigène Voir toutes JAG1 Anticorps
- JAG1 (Jagged 1 (JAG1))
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Épitope
- AA 110-125
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp JAG1 est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)
- Purification
- Protein A Column
- Immunogène
- JAG1 antibody was raised against a synthetic peptide corresponding to aa 110 - 125 of JAG1 (Human).
- Isotype
- IgG
- Top Product
- Discover our top product JAG1 Anticorps primaire
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- Indications d'application
- JAG1 antibody can be used in Western Blot starting at 1:500 - 1:1000, immunohistochemistry starting at 5 μg/mL, and immunocytochemistry.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS, pH 7.2, 0.01 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- As with all antibodies avoid freeze/thaw cycles.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store JAG1 antibody at 4 °C or -20 °C.
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- Antigène
- JAG1 (Jagged 1 (JAG1))
- Autre désignation
- JAG1 (JAG1 Produits)
- Synonymes
- anticorps AGS, anticorps AHD, anticorps AWS, anticorps CD339, anticorps HJ1, anticorps JAGL1, anticorps ABE2, anticorps Gsfabe2, anticorps Htu, anticorps Ozz, anticorps Ser-1, anticorps JAG1, anticorps jag3, anticorps cb243, anticorps jag1, anticorps sb:cb243, anticorps serrateC, anticorps jagged1, anticorps serrate, anticorps serrate-1, anticorps x-serrate-1, anticorps jagged 1, anticorps jagged 1b, anticorps jagged 1a, anticorps jagged 1 L homeolog, anticorps JAG1, anticorps Jag1, anticorps jag1, anticorps jag1b, anticorps jag1a, anticorps jag1.L
- Sujet
- Jagged-1 (JAG1) is a cell surface protein which is one of several ligands that activate Notch and related receptors. JAG1 functions in an embryologically important signaling pathway and has also been shown to play a role in hematopoiesis. JAG1 inhibits proliferation of cd34+ macrophage progenitor cells and a JAG1 gene abnormality may be an aggravating factor in extrahepatic biliary atresia. Activation of NOTCH1 signaling by JAG1 induces monocyte-derived dendritic cell maturation in vitro. JAG1 interaction with NOTCH1 on tumor cells dramatically induces proliferation and inhibition of apoptosis in vitro. Either haploinsufficiency for wild-type JAG1 and/or dominant negative effects produced by mutated JAG1 are responsible for the Alagille syndrome. A BLAST analysis was used to suggest crossreactivity with Jagged-1 protein from human, chimpanzee, rat and mouse based on 100 % homology with the immunizing sequence. Partial reactivity is expected against canine (81 %) and Xenopus laevis (85 %) based on partial sequence homologies as indicated. The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.
- ID gène
- 182
- UniProt
- P78504
- Pathways
- Signalisation Notch, Stem Cell Maintenance
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