Fibrinogen anticorps

N° du produit ABIN264639

Cet anticorps anti-Fibrinogen est un anticorps Lapin Polyclonal détectant Fibrinogen dans WB et EIA. Adapté pour Souris. Ce Primary Antibody a été cité dans 2+ publications.

Aperçu rapide pour Fibrinogen anticorps (ABIN264639)

Antigène: Fibrinogen

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Fibrinogen est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Détail du produit anti-Fibrinogen anticorps

Réactivité croisée (Details): Species reactivity (tested):Mouse.

Purification: Protein A Chromatography.

Immunogène: Native Mouse Fibrinogen.

Information d'application

Indications d'application: ELISA. Western Blot.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 17.0 mg/mL (OD280nm, E0.1% = 1.36)

Buffer: 0.05 M Sodium Phosphate, pH 6.6 containing 0.5 M Sodium Chloride and 1 mM EDTA, None

Agent conservateur: Without preservative

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody at -20 °C to -70 °C.

Références pour anticorps anti-Fibrinogen (ABIN264639)

Fan, Xu, Wang, Luo, Zhu, Cai, Wei, Lu, Cao, Ye, Fan, Zhao: "Tissue Plasminogen Activator Neurotoxicity is Neutralized by Recombinant ADAMTS 13." dans: Scientific reports, Vol. 6, pp. 25971, (2016) (PubMed).

Langhauser, Göb, Kraft, Geis, Schmitt, Brede, Göbel, Helluy, Pham, Bendszus, Jakob, Stoll, Meuth, Nieswandt, McCrae, Kleinschnitz: "Kininogen deficiency protects from ischemic neurodegeneration in mice by reducing thrombosis, blood-brain barrier damage, and inflammation." dans: Blood, Vol. 120, Issue 19, pp. 4082-92, (2012) (PubMed).

Détails sur Fibrinogen

Antigène: Fibrinogen

Sujet: Fibrinogen is the main protein of blood coagulation system. It is a large protein and it consists of two identical subunits that contain three polypeptide chains: alpha, beta and gamma. All chains are connected with each other by a number of disulfide bonds. Fibrinopeptides A (1 to 16 amino acids) and B (1 to 17 amino acids) are released by thrombin from the N terminal parts of alpha and beta chains, respectively. In this way fibrinogen is converted into fibrin, which by means of polymerization forms a fibrin clot. Fibrinogen clotting underlies pathogenesis of MI, thromboembolism and thromboses of arteries and veins, since fibrin is the main substrate for thrombus formation. Fibrinogen activation is also involved in pathogenesis of inflammation, tumor growth and many other diseases. The normal fibrinogen concentration in plasma is about 3 mg/mL. The elevated level of fibrinogen in patient's blood is regarded as an independent risk factor for cardiovascular diseases. An increase in blood fibrinogen concentration was shown to be a strong predictor of coronary heart disease (Sonel A. et al, and Rapold H.J. et al). All these facts make fibrinogen an important parameter in the diagnosis of cardiovascular diseases.Synonyms: FGA, FGB, FGG