BACE2 anticorps (AA 44-59)

N° du produit ABIN264996

Détail du produit anti-BACE2 anticorps

Antigène: BACE2 (beta-Site APP-Cleaving Enzyme 2 (BACE2))

Épitope: AA 44-59

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BACE2 est non-conjugé

Application: Western Blotting (WB)

Specificité: This antibody reacts to BACE 2.

Purification: Purified

Immunogène: Synthetic peptide corresponding to amino acids 44 to 59 of human BACE2

Isotype: IgG

Information d'application

Indications d'application: Western Blot: 0.5 to 1 μg/mL. Detects an approximately 70 kDa band in human heart tissuelysate.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: Phosphate buffered saline solution containing 0.02 % sodium azide as a preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.

Détails sur BACE2

Antigène: BACE2 (beta-Site APP-Cleaving Enzyme 2 (BACE2))

Autre désignation: BACE2 (BACE2 Produits)

Synonymes: anticorps AEPLC, anticorps ALP56, anticorps ASP1, anticorps ASP21, anticorps BAE2, anticorps CEAP1, anticorps DRAP, anticorps 1110059C24Rik, anticorps AI850424, anticorps ARP1, anticorps CDA13, anticorps beta-site APP-cleaving enzyme 2, anticorps BACE2, anticorps Bace2

Sujet: Accumulation of the amyloid-b (Ab) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. Ab peptide is generated by proteolytic cleavage of the b-amyloid protein precursor (APP) at b- and g -sites by proteases. The long-sought b-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2)1-4. A BACE homolog was recently cloned and designated BACE2, Asp1, DRAP (for Down region aspartic protease), and memapsin 14 - 9. BACE2 also cleaves APP at b-site and at a different site within Ab8. BACE2 locates on chromosome 21q22.3, the so-called Down critical region, suggesting that BACE2 and Ab may also contribute to the pathogenesis of Down syndrome.Synonyms: AEPLC, ALP56, ASP1, ASP21, Aspartic-like protease 56 kDa, Aspartyl protease 1, Beta-secretase 2, Beta-site APP-cleaving enzyme 2, Down region aspartic protease, Memapsin-1, Membrane-associated aspartic protease 1

ID gène: 25825

NCBI Accession: NP_036237

UniProt: Q9Y5Z0