Clusterin anticorps (Isoform 1)

N° du produit ABIN265125

Cet anticorps anti-Clusterin Polyclonal Lapin (ABIN265125) détecte spécifiquement Clusterin dans WB. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Clusterin anticorps (Isoform 1) (ABIN265125)

Antigène: Clusterin (CLU)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Clusterin est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Clusterin anticorps

Épitope: Isoform 1

Specificité: This antibody reacts to Apolipoprotein J (Clusterin).

Purification: Purified

Immunogène: Rabbit polyclonal Clusterin antibody was raised recombinant human Clusterin isoform 1.

Isotype: IgG

Information d'application

Indications d'application: Western Blot: 0.5 - 1 μg/mL. Positive Control: Human Brain Tissue Lysate used as positive control. Clusterin is known tobe expressed in a variety of tissues and it seems to be able to bind to cells, membranesand hydrophobic proteins.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: Phosphate buffered saline with 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.

Détails sur Clusterin

Antigène: Clusterin (CLU)

Autre désignation: Apolipoprotein J (Apo J)

Sujet: Clusterin, also known as Apolipoprotein J (ApoJ), is a ubiquitous multifunctional glycoprotein that can interact with a broad spectrum of molecules such as complement components, various receptors, and the Alzheimer's b-amyloid peptide (1). Clusterin expression is increased in Alzheimer's disease brain tissue and clusterinimmunoreactive amyloid plaques are found associated with phospho-tau-positive dystrophic neurites (2) and it has been suggested that clusterin facilitates the conversion of diffuse bamyloid deposits into amyloid and enhances tau phosphorylation in neurites around these plaques. Other reports show that clusterin expression is decreased in proliferating cells and is upregulated in quiescent and senescent cells, suggesting that it may also play a role in aging and tumorigenesis suppression (3). Clusterin exists in at least two distinct isoforms.Synonyms: 40, 40, AAG4, APOJ, Aging-associated gene 4 protein, CLI, Clusterin, Complement cytolysis inhibitor, Complement-associated protein SP-40, KUB1, Ku70-binding protein 1, NA1/NA2, SP-40, Testosterone-repressed prostate message 2

ID gène: 1191

NCBI Accession: NP_976084

UniProt: P10909

Pathways: Apoptose, Negative Regulation of intrinsic apoptotic Signaling