IRF7 anticorps (C-Term)

N° du produit ABIN265129

Cet anticorps Lapin Polyclonal détecte spécifiquement IRF7 dans WB. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour IRF7 anticorps (C-Term) (ABIN265129)

Antigène: IRF7 (Interferon Regulatory Factor 7 (IRF7))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IRF7 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-IRF7 anticorps

Épitope: C-Term

Specificité: This antibody reacts to Interferon Regulatory Factor 7 (IRF7). Expressed predominantly in spleen, thymus and peripheral blood leukocytes, IRF7 is located in the nucleus and cytoplasm. The phosphorylated and active form accumulates selectivly in the nucleus.

Purification: Purified

Immunogène: Peptide corresponding to 14 amino acids near the carboxy-terminus of Human IRF7

Isotype: IgG

Information d'application

Indications d'application: Western Blot: 1-2 μg/mL. Positive control: Spleen, thymus and peripheral blood leukocytes.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline with 0.02 % Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.

Détails sur IRF7

Antigène: IRF7 (Interferon Regulatory Factor 7 (IRF7))

Autre désignation: IRF7

Sujet: Interferons (IFNs) are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms. During infection, host-virus interactions signal downstream molecules such as transcription factors such as IFN regulatory factor-3 (IRF3) which can act to stimulate transcription of IFN-a/b genes. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. IRF7 play a major role in the innate immune pathway, interacting with the Toll-like receptor (TLR) adaptor proteins MyD88 and Tirp/TRAM and functioning as an intermediate TLR4 and TLR9 signaling. There are at least four differentially spliced isoforms of IRF7, although their function has not been clearly established.Synonyms: IRF-7, Interferon regulatory factor 7

ID gène: 3665

NCBI Accession: NP_001563

UniProt: Q92985

Pathways: Signalisation TLR, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, Autophagy