IRF7 anticorps (Middle Region)

N° du produit ABIN265130

L’anticorps Lapin Polyclonal anti-IRF7 a été validé pour WB. Il convient pour détecter IRF7 dans des échantillons de Humain.

Aperçu rapide pour IRF7 anticorps (Middle Region) (ABIN265130)

Antigène: IRF7 (Interferon Regulatory Factor 7 (IRF7))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IRF7 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-IRF7 anticorps

Épitope: Middle Region

Specificité: This antibody reacts to Interferon regulatory factor 7 (IRF7).

Purification: Purified

Immunogène: Rabbit polyclonal IRF7 antibody was raised against a peptide corresponding to 14 amino acids near the center of human IRF7

Isotype: IgG

Information d'application

Indications d'application: Western Blot: 1 - 2 μg/mL. Expressed predominantly in spleen, thymus and peripheral blood leukocytes, IRF7 islocated in the nucleus and cytoplasm. The phosphorylated and active form accumulatesselectivly in the nucleus.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: Phosphate buffered saline with 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.

Détails sur IRF7

Antigène: IRF7 (Interferon Regulatory Factor 7 (IRF7))

Autre désignation: IRF7

Sujet: Interferons (IFNs) are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms. During infection, host-virus interactions signal downstream molecules such as transcription factors such as IFN regulatory factor-3 (IRF3) which can act to stimulate transcription of IFN-alpha/beta genes. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. IRF7 play a major role in the innate immune pathway, interacting with the Toll-like receptor (TLR) adaptor proteins MyD88 and Tirp/TRAM and functioning as an intermediate TLR4 and TLR9 signaling (3,4). There are at least four differentially spliced isoforms of IRF7, although their function has not been clearly established.Synonyms: IRF-7, Interferon regulatory factor 7

ID gène: 3665

NCBI Accession: NP_001563

UniProt: Q92985

Pathways: Signalisation TLR, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, Autophagy