Filamin A anticorps

N° du produit ABIN265421

Détail du produit anti-Filamin A anticorps

Antigène: Filamin A (FLNA) (Filamin A, alpha (FLNA))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Filamin A est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: This antibody detects endogenous levels of Filamin A protein. (region surrounding Arg5146)

Réactivité croisée (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Affinity Chromatography using epitope-specific immunogen

Information d'application

Indications d'application: ELISA: 1: 1000approx. 1: 10000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur Filamin A

Antigène: Filamin A (FLNA) (Filamin A, alpha (FLNA))

Autre désignation: Filamin-A (FLNA Produits)

Synonymes: anticorps ABP-280, anticorps ABPX, anticorps CSBS, anticorps CVD1, anticorps FLN, anticorps FLN-A, anticorps FLN1, anticorps FMD, anticorps MNS, anticorps NHBP, anticorps OPD, anticorps OPD1, anticorps OPD2, anticorps XLVD, anticorps XMVD, anticorps fb98b06, anticorps wu:fb98b06, anticorps wu:fd09g03, anticorps wu:fd49a06, anticorps Dilp2, anticorps F730004A14Rik, anticorps Fln1, anticorps filamin-1, anticorps RGD1560614, anticorps MGC147094, anticorps CG3937, anticorps Cher, anticorps Dmel\\CG3937, anticorps Fil, anticorps joy, anticorps sko, anticorps filamin A, anticorps filamin A, alpha (actin binding protein 280), anticorps filamin, alpha, anticorps filamin-A, anticorps cheerio, anticorps FLNA, anticorps flna, anticorps Flna, anticorps LOC587317, anticorps cher, anticorps LOC100380643

Sujet: Caldesmon, Filamin 1, nebulin and villin are differentially expressed and regulated Actin binding proteins. Both muscular (CDh) and non-muscular (CDl) forms of caldesmon have been identified and each has been shown to bind to Actin as well as to calmodulin and Myosin. CDh is expressed predominantly on thin filaments in smooth muscle, whereas CDl is widely expressed in nonmuscle tissues and cells. Filamin 1, which is ubiquitously expressed and exists as a homodimer, functions to crosslink Actin to filaments. Nebulin is a large filamentous protein specific to muscle tissue that may function as a ruler for filament length. Several isoforms of nebulin, ranging from 700 to 900 kDa, are produced by alternative exon usage. Villin is Ca2+-regulated and is the major structural component of the brush border of absorptive cells.Synonyms: Actin-binding protein 280, Alpha-filamin, Endothelial actin-binding protein, FLN, FLN1, FLNA, Filamin-1, Non-muscle filamin

Poids moléculaire: approx. 280 kDa

ID gène: 2316

NCBI Accession: NP_001104026

UniProt: P21333

Pathways: TCR Signaling, Maintenance of Protein Location