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ERBB3 anticorps (APC)

ERBB3 Reactivité: Humain FACS, ICFC Hôte: Souris Monoclonal 1B4C3 APC
N° du produit ABIN2658752
  • Antigène Voir toutes ERBB3 Anticorps
    ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))
    Reactivité
    • 190
    • 132
    • 117
    • 17
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 191
    • 32
    • 1
    • 1
    Souris
    Clonalité
    • 191
    • 34
    Monoclonal
    Conjugué
    • 112
    • 14
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 1
    Cet anticorp ERBB3 est conjugé à/à la APC
    Application
    • 101
    • 70
    • 53
    • 53
    • 51
    • 30
    • 30
    • 23
    • 20
    • 17
    • 8
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    Flow Cytometry (FACS), Intracellular Flow Cytometry (ICFC)
    Purification
    The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions. The solution is free of unconjugated APC and unconjugated antibody.
    Clone
    1B4C3
    Isotype
    IgG2a kappa
    Top Product
    Discover our top product ERBB3 Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Buffer
    Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Protect from prolonged exposure to light. Do not freeze.
    Stock
    4 °C
    Stockage commentaire
    The antibody solution should be stored undiluted between 2°C and 8°C.
  • Antigène
    ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))
    Autre désignation
    ErbB3/HER-3 (ERBB3 Produits)
    Synonymes
    anticorps ErbB-3, anticorps HER3, anticorps LCCS2, anticorps MDA-BF-1, anticorps c-erbB-3, anticorps c-erbB3, anticorps erbB3-S, anticorps p180-ErbB3, anticorps p45-sErbB3, anticorps p85-sErbB3, anticorps ERBB3, anticorps C76256, anticorps Erbb-3, anticorps Erbb3r, anticorps Her3, anticorps nuc-ErbB3, anticorps erb-b2 receptor tyrosine kinase 3, anticorps v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian), anticorps ERBB3, anticorps Erbb3
    Sujet
    ErbB3/HER3 is a receptor tyrosine kinase and a member of the epidermal growth factor receptor family. erbB3/HER3 binds the heregulin ligands and contains 4 furin-like repeats, 2 cheY receiver domains, and a tyrosine kinase domain with a predicted molecular weight approximately 148 kD. Signaling through the erbB3/HER3 receptor induces proliferation and differentiation in some cell types, the receptor is widely expressed in many tissues including kidney, lung, brain, placenta, skin and stomach. erbB3/HER3 forms constitutively active heterodimers with erbB2/HER2 in a subset of human mammary tumors, expression of erbB3/HER3 reported be linked to favorable outcome in bladder and ovarian cancer. erbB3/HER3 has been shown to interact with a number of proteins including EGF receptor, erbB2/HER2, erbB4, Grb2, Grb7, SOS1, cdk5, SHC, FAK, PTK6, and others. The erbB3/HER3 receptor is extensively phosphorylated at residues T873 and S1123 (by cdk5), Y1199, Y1262, Y1289, and Y1328. The 1B4C3 antibody has been shown to be useful for flow cytometric detection of human erbB3/HER3.
    Pathways
    Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
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