CSF1R anticorps (PE-Cy7)

N° du produit ABIN2659066

Détail du produit anti-CSF1R anticorps (PE-Cy7)

Antigène: CSF1R (Colony Stimulating Factor 1 Receptor (CSF1R))

Reactivité: Humain

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp CSF1R est conjugé à/à la PE-Cy7

Application: Flow Cytometry (FACS)

Purification: The antibody was purified by affinity chromatography and conjugated with PE/Cy7 under optimal conditions. The solution is free of unconjugated PE/Cy7 and unconjugated antibody.

Clone: 9-4D2-1E4

Isotype: IgG1 kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Protect from prolonged exposure to light. Do not freeze.

Stock: 4 °C

Stockage commentaire: The antibody solution should be stored undiluted between 2°C and 8°C.

Détails sur CSF1R

Antigène: CSF1R (Colony Stimulating Factor 1 Receptor (CSF1R))

Autre désignation: CD115 (CSF1R Produits)

Synonymes: anticorps AI323359, anticorps CD115, anticorps CSF-1R, anticorps Csfmr, anticorps Fim-2, anticorps Fms, anticorps M-CSF-R, anticorps M-CSFR, anticorps C-FMS, anticorps CSFR, anticorps FIM2, anticorps FMS, anticorps HDLS, anticorps PDGFRB, anticorps MGC89146, anticorps CSF-1-R, anticorps c-fms, anticorps mrfms, anticorps CSF1, anticorps M-CSF, anticorps csf1r, anticorps fms, anticorps panther, anticorps colony stimulating factor 1 receptor, anticorps macrophage colony-stimulating factor receptor, anticorps colony stimulating factor 1 receptor, a, anticorps Csf1r, anticorps CSF1R, anticorps m-csfr, anticorps csf1r, anticorps csf1ra

Sujet: CSF-1R, also known as CD115 and M-CSFR, is a single-pass type I membrane protein and member of the platelet-derived growth factor receptor family. Structural studies of CD115 have described an Ig-like extracellular domain, a transmembrane domain, an intracellular juxtamembrane domain, a split tyrosine kinase domain, and a C-terminal tail receptor. Receptor activation induces homodimerization in addition to phosphorylation and ubiquitinylation of intracellular residues. The natural ligands of CD115 include M-CSF and IL-34. CD115 directly influences tissue macrophage and osteoclast differentiation and proliferation. It is expressed on monocytes/macrophages, plasmacytoid and conventional dendritic cells, and osteoclasts.

Pathways: Signalisation RTK, Inositol Metabolic Process, Cell-Cell Junction Organization