C5AR1 anticorps

N° du produit ABIN2664087

L’anticorps anti-C5AR1 Monoclonal Souris est utilisé pour la détection de C5AR1 dans des échantillons de Humain. Il a été validé pour FACS, IF et IP.

Aperçu rapide pour C5AR1 anticorps (ABIN2664087)

Antigène: C5AR1 (Complement Component 5a Receptor 1 (C5AR1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp C5AR1 est non-conjugé

Application: Flow Cytometry (FACS), Immunofluorescence (IF), Immunoprecipitation (IP)

Clone: C17-5

Détail du produit anti-C5AR1 anticorps

Purification: The antibody was purified by affinity chromatography.

Isotype: IgG1 kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: The antibody solution should be stored undiluted between 2°C and 8°C.

Détails sur C5AR1

Antigène: C5AR1 (Complement Component 5a Receptor 1 (C5AR1))

Autre désignation: C5a/C5a

Sujet: C5, complement component 5, is a protein involved in the complement system. It is cleaved into C5a and C5b by the C3/C5 convertase. The smaller fragment C5a is an anaphylatoxin and is released into the fluid surroundings. C5a is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C5a also stimulates the locomotion of polymorphonuclear leukocytes (chemokinesis) and direct their migration toward sites of inflammation (chemotaxis). C5a contains 74 amino acids and is rapidly metabolised by a serum enzyme, carboxypeptidase B to a 73 amino acid form, C5a des-Arg. The major fragment C5b binds to the membrane initiating the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex.

Pathways: Système du Complément