Caspase 1 anticorps

N° du produit ABIN2664090

Cet anticorps Rat Monoclonal détecte spécifiquement Caspase 1 dans FACS. Il présente une réactivité envers Souris.

Aperçu rapide pour Caspase 1 anticorps (ABIN2664090)

Antigène: Caspase 1 (CASP1)

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp Caspase 1 est non-conjugé

Application: Flow Cytometry (FACS)

Clone: 5B10

Détail du produit anti-Caspase 1 anticorps

Purification: The antibody was purified by affinity chromatography.

Isotype: IgG2a

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: The antibody solution should be stored undiluted between 2°C and 8°C.

Détails sur Caspase 1

Antigène: Caspase 1 (CASP1)

Autre désignation: Caspase-1

Sujet: Caspase -1 plays a vital role in cleaving the inactive procytokine pro-IL-1 beta to generate the active 17 kd mature form of IL-1beta, a key mediator of inflammation. Active caspase-1 (ICE) is derived a single proenzyme of 45 Kd. An active ICE comprises two subunits of P20 and two subunits of P10 after removal a large amino-terminal pro-domain and a small linker peptide. Caspase-1 is reported to be involved in CD95- mediated apoptosis. Four alternatively spliced variants of caspase-1 have been reported, with mw ranging from 30-48 kd.

Pathways: Apoptose, Interferon-gamma Pathway, Positive Regulation of Endopeptidase Activity, Inflammasome