SIGLEC5 anticorps

N° du produit ABIN2664288

Cet anticorps Souris Monoclonal détecte spécifiquement SIGLEC5 dans ICFC. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour SIGLEC5 anticorps (ABIN2664288)

Antigène: SIGLEC5 (Sialic Acid Binding Ig-Like Lectin 5 (SIGLEC5))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SIGLEC5 est non-conjugé

Application: Intracellular Flow Cytometry (ICFC)

Clone: 1A5

Détail du produit anti-SIGLEC5 anticorps

Réactivité croisée: Chimpanzé, Bonobo, Gorilla

Purification: The antibody was purified by affinity chromatography.

Isotype: IgG1 kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: The antibody solution should be stored undiluted between 2°C and 8°C.

Détails sur SIGLEC5

Antigène: SIGLEC5 (Sialic Acid Binding Ig-Like Lectin 5 (SIGLEC5))

Autre désignation: CD170

Sujet: CD170, also known as Siglec-5, is a single pass transmembrane protein member of the immunoglobulin superfamily. On the cell surface, CD170 forms a 140 kD dimer. The cytoplasmic domain of Siglec-5 contains two ITIM motifs that recruit the tyrosine-phosphatases SHP-1 and SHP-2 after tyrosine-phosphorylation, which in turn results in the inhibition of cell signaling. Siglec-5 is expressed by granulocytes, monocytes/macrophages, subsets of lymphocytes, and a subset of activated dendritic cells. Siglec-5 binds α2,3- and α2,6-linked sialic acid as well as glycophorin A, and is involved in cell adhesion.