Lamin A/C anticorps

N° du produit ABIN2666170

Cet anticorps anti-Lamin A/C est un anticorps Lapin Polyclonal détectant Lamin A/C dans FACS et BR. Adapté pour Humain et Souris.

Aperçu rapide pour Lamin A/C anticorps (ABIN2666170)

Antigène: Lamin A/C (LMNA)

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Lamin A/C est non-conjugé

Application: Flow Cytometry (FACS), Blocking Reagent (BR)

Clone: Poly6135

Détail du produit anti-Lamin A/C anticorps

Réactivité croisée (Details): weakly cross-reactive with Mouse

Purification: The antibody was purified by antigen-affinity chromatography.

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Upon receipt, store frozen at -20°C.

Détails sur Lamin A/C

Antigène: Lamin A/C (LMNA)

Autre désignation: Lamin A

Sujet: Lamin A is a member of the intermediate filament family that contains a farnesyl binding domain and forms dimers. Three isoforms of Lamin A have been reported designated A, AD10, C, with molecular weights of approximately 70 kD, 66 kD, and 61 kD, respectively. Lamin A is localized to the nucleoplasmic side of inner nuclear membrane. Lamin A is thought to function as a fibrous component of the nuclear lamina, providing a framework for the nuclear envelope, and possibly interacting with chromatin. Expression of lamin A is strictly under cell cycle control as seen by disintegration/formation of nuclear envelope in prophase/telophase. Lamin A is modified by phosphorylation, methylation, and farnesylation, phosphorylation regulates disassembly. Lamin A forms a homodimer with Lamin C and has also been shown to interact with the LAPs 1A-1C, emerin, Narf, hsMOK2, PKC, SREBP1a, and SREBP 1c. The Poly6135 antibody recognizes the C-terminal region of human and mouse Lamin A and has been shown to be useful for Western blotting and immunofluorescence staining.

Pathways: Apoptose, Caspase Cascade in Apoptosis, ER-Nucleus Signaling, Protein targeting to Nucleus