IRF9 anticorps

N° du produit ABIN2666230

L’anticorps Souris Monoclonal anti-IRF9 a été validé pour FACS. Il convient pour détecter IRF9 dans des échantillons de Humain.

Aperçu rapide pour IRF9 anticorps (ABIN2666230)

Antigène: IRF9 (Interferon Regulatory Factor 9 (IRF9))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp IRF9 est non-conjugé

Application: Flow Cytometry (FACS)

Clone: 5A3A39

Détail du produit anti-IRF9 anticorps

Purification: Affinity purified.

Isotype: IgG2b kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Upon receipt, store undiluted 2°C and 8°C.

Détails sur IRF9

Antigène: IRF9 (Interferon Regulatory Factor 9 (IRF9))

Autre désignation: IRF9

Sujet: IRF9 is a member of the IRF family of transcription factors and plays an important role in IFN signaling pathways and anti-viral immune responses. Type I and type III interferon stimulation induces phosphorylation and heterodimerization of STAT1 and STAT2. The activated STAT1:STAT2 heterodimer recruits IRF9 and forms a heterotrimeric complex termed IFN-stimulated gene factor 3 (ISGF3). The ISGF3 complex, in turn, translocates to the nucleus and transactivates IFN-inducible genes. The IRF9 protein in the ISGF3 complex is responsible for the recognition of IFN-stimulated response elements (ISRE). Mice lacking IRF9 fail to induce the expression of IFN regulated genes in response to type I interferon stimulation, indicating that IRF9 is crucial in mediating interferon signaling.

Pathways: Signalistation JAK/STAT, Interferon-gamma Pathway, Hepatitis C