NCOR2 anticorps (AA 2004-2310)

N° du produit ABIN2668570

Il existe 1 publication pour ce produit. L’anticorps anti-NCOR2 Monoclonal Souris est utilisé pour la détection de NCOR2 dans des échantillons de Humain. Il a été validé pour WB.

Aperçu rapide pour NCOR2 anticorps (AA 2004-2310) (ABIN2668570)

Antigène: NCOR2 (Nuclear Receptor Co-Repressor 2 (NCOR2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp NCOR2 est non-conjugé

Application: Western Blotting (WB)

Clone: 5-10

Détail du produit anti-NCOR2 anticorps

Épitope: AA 2004-2310

Fonction: SMRT / NCoR2 antibody (mAb) (Clone 5.10)

Purification: Protein G Chromatography

Immunogène: This SMRT / NCoR2 antibody was raised against a recombinant protein corresponding to amino acids 2004-2310 of human SMRT / NCoR2.

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1 μg/μL

Buffer: Purified IgG in 70 mM Tris ( pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30 % glycerol and 0.035 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Stock: -20 °C

Stockage commentaire: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Date de péremption: 24 months

Références pour anticorps anti-NCOR2 (ABIN2668570)

Huang, Zhang, Miska, Guenther, Kouzarides, Lazar: "Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway." dans: Genes & development, Vol. 14, Issue 1, pp. 45-54, (2000) (PubMed).

Détails sur NCOR2

Antigène: NCOR2 (Nuclear Receptor Co-Repressor 2 (NCOR2))

Autre désignation: SMRT / NCoR2

Sujet: SMRT / NCoR2 (Nuclear receptor corepressor 2, CTG repeat protein 26, SMAP270, Silencing mediator of retinoic acid and thyroid hormone receptor, Thyroid and retinoic-acid-receptor-associated corepressor, TRAC) is a transcriptional corepressor for nuclear receptors. SMRT / NCoR2 has been shown to play a role in regulating immune response, mediating DNA repair, and in neuronal differentiation and cardiac development. SMRT / NCoR2 is part of a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. It also includes TBL1, TBLR1, and GPS2 that help stabilize the overall structure of the complex. SMRT / NCoR2 mediates the transcriptional repression activity of nuclear receptors by promoting histone deacetylation and chromatin condensation, thus preventing access of the basal transcription machinery.

Poids moléculaire: 300 kDa

ID gène: 9612

NCBI Accession: NP_006303

Pathways: Signalisation Notch, Carbohydrate Homeostasis, Chromatin Binding, Regulation of Lipid Metabolism by PPARalpha