WWTR1 anticorps (C-Term)

N° du produit ABIN2668074

Cet anticorps anti-WWTR1 Polyclonal Lapin (ABIN2668074) détecte spécifiquement WWTR1 dans WB. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour WWTR1 anticorps (C-Term) (ABIN2668074)

Antigène: WWTR1 (WW Domain Containing Transcription Regulator 1 (WWTR1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp WWTR1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-WWTR1 anticorps

Épitope: C-Term

Fonction: TAZ / WWTR1 antibody (pAb)

Purification: Affinity Purified

Immunogène: TAZ / WWTR1 antibody was raised against a peptide corresponding to the C-terminal region of human TAZ / WWTR1.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500 - 1:1,000 dilution

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.15 μg/μL

Buffer: Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Stock: -20 °C

Stockage commentaire: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Date de péremption: 24 months

Détails sur WWTR1

Antigène: WWTR1 (WW Domain Containing Transcription Regulator 1 (WWTR1))

Autre désignation: TAZ / WWTR1

Sujet: The TAZ / WWTR1 (Transcriptional coactivator with PDZ-binding motif, WW domain-containing transcription regulator protein 1) gene encodes a protein that is a transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.

Poids moléculaire: 55 kDa

ID gène: 25937

NCBI Accession: NP_056287

Pathways: Regulation of Lipid Metabolism by PPARalpha