IGF1R anticorps

N° du produit ABIN2689097

Cet anticorps Souris Monoclonal détecte spécifiquement IGF1R dans IF et FACS. Il présente une réactivité envers Humain et a été mentionné dans 2+ publications.

Aperçu rapide pour IGF1R anticorps (ABIN2689097)

Antigène: IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp IGF1R est non-conjugé

Application: Immunofluorescence (IF), Flow Cytometry (FACS)

Clone: 3B7

Détail du produit anti-IGF1R anticorps

Marque: BD Pharmingen™

Attributs du produit: Reacts with human insulin-like growth factor-I (IGF-I) receptor. IGF-I receptor is a glycoprotein complex composed of two extracellular α subunits and two transmembrane β subunits. The transmembrane subunits play a role in tyrosine phosphorylation of several intracellular signaling proteins. IGF-I receptor is structurally and functionally similar to insulin receptor and is expressed on a variety of human hematopoietic and non-hematopoietic cells. 3B7 antibody does not cross react with human insulin receptor, it stimulates IGF-I and IGF-II induced cell growth and activates autophosphorylation of the IGF-I receptor β subunit. Profile of Jurkat Cells analyzed on a FACScan with Biotin Goat anti-mouse Ig (Cat. No. 553999) as 2nd step, and with SAV-PE (Cat. No. 554061) as 3rd step. CD221 expression (filled) and isotype control (dash lines)

BD Pharmingen™ Purified Mouse Anti-Human CD221 - Purified - Clone 3B7 - Isotype Mouse IgG1, κ - Reactivity Hu - 0.1 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Isotype: IgG1 kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store undiluted at 4°C.

Références pour anticorps anti-IGF1R (ABIN2689097)

Kooijman, Scholtens, Rijkers, Zegers: "Differential expression of type I insulin-like growth factor receptors in different stages of human T cells." dans: European journal of immunology, Vol. 25, Issue 4, pp. 931-5, (1995) (PubMed).

Xiong, Kasuya, Li, Kato, Fujita-Yamaguchi: "Growth-stimulatory monoclonal antibodies against human insulin-like growth factor I receptor." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 12, pp. 5356-60, (1992) (PubMed).

Détails sur IGF1R

Antigène: IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))

Autre désignation: CD221

Sujet: Synonyms: IGF-I receptor

Pathways: Signalisation RTK, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Autophagy