CD25 anticorps

N° du produit ABIN2689119

Il existe 4+ publications pour ce produit. L’anticorps anti-CD25 Monoclonal Souris est utilisé pour la détection de CD25 dans des échantillons de Rat. Il a été validé pour FACS, IP, IHC (fro) et BR.

Aperçu rapide pour CD25 anticorps (ABIN2689119)

Antigène: CD25 (IL2RA) (Interleukin 2 Receptor, alpha (IL2RA))

Reactivité: Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD25 est non-conjugé

Application: Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Blocking Reagent (BR)

Clone: OX

Détail du produit anti-CD25 anticorps

Attributs du produit: The OX-39 antibody reacts with the α chain of the IL-2 receptor on T lymphoblasts and thymic and splenic dendritic cells. CD25 has also been detected on rat intestinal epithelial cells. It has been reported that OX-39 mAb weakly blocks binding of IL-2 to T-cell blasts and that it blocks IL-2 stimulated epithelial cell migration in an in vitro model of wound healing. Use of this product can fall under one or more claims of the following patents licensed to Becton, Dickinson and Company: US Patent Nos. 5,445,939, 5,656,446, 5,843,689, European Patent No. 319,543, Canadian Patent No. 1,296,622, Australian Patent No. 615,880, and Japanese Patent No. 2,769,156. This antibody is routinely tested by flow cytometric analysis. Other applications were tested during antibody development only or reported in the literature.

BD Pharmingen™ Purified Mouse Anti-Rat CD25 - Purified - Clone OX-39 - Isotype Mouse IgG1, κ - Reactivity Rat - 0.1 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Rat T blasts from mixed-lymphocyte reactions

Isotype: IgG1 kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store undiluted at 4°C.

Références pour anticorps anti-CD25 (ABIN2689119)

Josien, Heslan, Soulillou, Cuturi: "Rat spleen dendritic cells express natural killer cell receptor protein 1 (NKR-P1) and have cytotoxic activity to select targets via a Ca2+-dependent mechanism." dans: The Journal of experimental medicine, Vol. 186, Issue 3, pp. 467-72, (1997) (PubMed).

Dignass, Podolsky: "Interleukin 2 modulates intestinal epithelial cell function in vitro." dans: Experimental cell research, Vol. 225, Issue 2, pp. 422-9, (1996) (PubMed).

Paterson, Jefferies, Green, Brandon, Corthesy, Puklavec, Williams: "Antigens of activated rat T lymphocytes including a molecule of 50,000 Mr detected only on CD4 positive T blasts." dans: Molecular immunology, Vol. 24, Issue 12, pp. 1281-90, (1988) (PubMed).

Tellides, Dallman, Kupiec-Weglinski, Diamantstein, Morris: "Functional blocking of the interleukin-2 receptor (IL-2R) may be important in the efficacy of IL-2R antibody therapy." dans: Transplantation proceedings, Vol. 19, Issue 5, pp. 4231-3, (1987) (PubMed).

Détails sur CD25

Antigène: CD25 (IL2RA) (Interleukin 2 Receptor, alpha (IL2RA))

Autre désignation: CD25

Sujet: Synonyms: IL-2R α Chain

Pathways: Signalistation JAK/STAT, Growth Factor Binding, Activated T Cell Proliferation