NGFR anticorps

N° du produit ABIN2689134

L’anticorps Souris Monoclonal anti-NGFR a été validé pour FACS, IHC et FM. Il convient pour détecter NGFR dans des échantillons de Humain. Il y a 2+ publications disponibles.

Aperçu rapide pour NGFR anticorps (ABIN2689134)

Antigène: NGFR (Nerve Growth Factor Receptor (NGFR))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp NGFR est non-conjugé

Application: Flow Cytometry (FACS), Immunohistochemistry (IHC), Fluorescence Microscopy (FM)

Clone: C40

Détail du produit anti-NGFR anticorps

Marque: BD Pharmingen™

Attributs du produit: Reacts with nerve growth factor receptor (NGFR), a 75 kD protein that has been found localized to neuronal axons, Schwann cells, and perineural cells of peripheral nerves. It has also been found in some epithelial, mesenchymal and lymphoid tissues. NGFR is the receptor for nerve growth factor (NGF), a polypeptide that is essential for normal development of the nervous system. NGF promotes survival and differentiation of sympathetic and sensory neurons during embryological development of peripheral neurons. NGF binds to two distinctive surface receptors, the p/140[prototrk] and p75[NGFR]. High affinity binding of NGF requires that both receptor molecules be expressed. NGFR has been found on human and rat lymphocytes. A subset of lymphoid cells in the spleen, lymph nodes, and follicular dentritic cells in germinal centers of reactive lymph nodes were found to express p75. It has been reported that NGFR interaction with its ligand, NGF, may play a role in immunoregulation. NGF may function as a B-cell growth factor. Profile of REH cell line analyzed by flow cytometry

BD Pharmingen™ Purified Mouse Anti-Human CD271 - Purified - Clone C40-1457 - Isotype Mouse IgG1, κ - Reactivity Hu - 0.1 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Isotype: IgG1 kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store undiluted at 4°C.

Références pour anticorps anti-NGFR (ABIN2689134)

Brodie, Gelfand: "Functional nerve growth factor receptors on human B lymphocytes. Interaction with IL-2." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 148, Issue 11, pp. 3492-7, (1992) (PubMed).

Hempstead, Martin-Zanca, Kaplan, Parada, Chao: "High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor." dans: Nature, Vol. 350, Issue 6320, pp. 678-83, (1991) (PubMed).

Détails sur NGFR

Antigène: NGFR (Nerve Growth Factor Receptor (NGFR))

Autre désignation: CD271

Sujet: Synonyms: NGF Receptor

Pathways: Signalisation NF-kappaB, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Growth Factor Binding