CD3 anticorps
-
- Antigène Voir toutes CD3 Anticorps
- CD3
-
Reactivité
- Rat
-
Hôte
- Souris
-
Clonalité
- Monoclonal
-
Conjugué
- Cet anticorp CD3 est non-conjugé
-
Application
- Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Western Blotting (WB), Cytotoxicity Test (CyTox)
- Marque
- BD Pharmingen™
- Attributs du produit
-
The G4.18 antibody reacts with the T-cell receptor-associated CD3 cell-surface antigen found on thymocytes, peripheral T lymphocytes, and dendritic epidermal T cells. It has been reported that CD3 expression is down-regulated within 24 hours in concanavalin A-stimulated rat T cells, and soluble mAb inhibits the allogeneic mixed-lymphocyte proliferative response and cell-mediated cytotoxicity to allogeneic target cells. In vivo treatment with G4.18 mAb prevents cardiac and skin allograft rejection, resulting in donor-specific tolerance. Pre-incubation of splenocytes with the alternate anti-rat CD3 monoclonal antibody, 1F4 (Cat. No. 556970), blocks staining with mAb G4.18.
BD Pharmingen™ Purified Mouse Anti-Rat CD3 - Purified - Clone G4.18 - Isotype Mouse IgG3, κ - Reactivity Rat - 0.1 mg - Purification
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- Immunogène
- PHA-stimulated rat lymph node and spleen cells
- Clone
- G4-18
- Isotype
- IgG3 kappa
- Top Product
- Discover our top product CD3 Anticorps primaire
-
-
- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
-
- Concentration
- 0.5 mg/mL
- Buffer
- Aqueous buffered solution containing protein stabilizer and ≤0.09 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C
- Stockage commentaire
- Store undiluted at 4°C.
-
-
Immunophenotyping analysis of peripheral blood, splenic, and thymic lymphocytes in male and female rats." dans: Journal of pharmacological and toxicological methods, Vol. 37, Issue 1, pp. 37-46, (1997) (PubMed).
: "Regulation of T-cell activation in the lung: alveolar macrophages induce reversible T-cell anergy in vitro associated with inhibition of interleukin-2 receptor signal transduction." dans: Immunology, Vol. 87, Issue 2, pp. 250-8, (1996) (PubMed).
: "Alloreactive natural killer cells in the rat: complex genetics of major histocompatibility complex control." dans: European journal of immunology, Vol. 25, Issue 5, pp. 1249-56, (1995) (PubMed).
: "Alveolar macrophages from humans and rodents selectively inhibit T-cell proliferation but permit T-cell activation and cytokine secretion." dans: Immunology, Vol. 84, Issue 1, pp. 142-7, (1995) (PubMed).
: "Induction of long-term specific tolerance to allografts in rats by therapy with an anti-CD3-like monoclonal antibody." dans: Transplantation, Vol. 55, Issue 3, pp. 459-68, (1993) (PubMed).
: "
-
Immunophenotyping analysis of peripheral blood, splenic, and thymic lymphocytes in male and female rats." dans: Journal of pharmacological and toxicological methods, Vol. 37, Issue 1, pp. 37-46, (1997) (PubMed).
-
- Antigène
- CD3
- Autre désignation
- CD3 (CD3 Produits)
- Synonymes
- anticorps CD3, anticorps AI504783, anticorps CD3epsilon, anticorps T3e, anticorps cd3-gamma, anticorps cd3g, anticorps cd3g-a, anticorps cd3g/d, anticorps cd3gd, anticorps t3g, anticorps CD3e molecule, anticorps CD3d molecule, anticorps CD3 antigen, epsilon polypeptide, anticorps CD3g molecule S homeolog, anticorps CD3E, anticorps CD3D, anticorps Cd3e, anticorps cd3g.S
- Pathways
- TCR Signaling, Ubiquitin Proteasome Pathway
-